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222 Assessment of the risk of flares in systemic lupus erythematosus
  1. M Minodora1,
  2. L Mazur-Nicorici2,
  3. V Sadovici-Bobeica3 and
  4. M Garabajiu3
  1. 1State Medical and Pharmaceutical University – Nicolae Testemitanu, Department of Internal Medicine, Chisinau, Moldova
  2. 2State Medical and Pharmaceutical University – Nicolae Testemitanu, Department of Internal Medicine Discipline Cardiology, Chisinau, Moldova
  3. 3State Medical and Pharmaceutical University – Nicolae Testemitanu, Department of Internal Medicine- Discipline Internal Medicine, Chisinau, Moldova

Abstract

Background and aims To evaluate the risc of flares in SLE patients

Methods A prospective analytic study of SLE patients (SLICC, 2012 criteria) with a fallowed–up in 5 visits: baseline visit, month 3, month 5, month 9 and month 12 visit. At visits disease activity (SLEDAI, SLAM), SELENA/SLEDAI flare index and laboratory tests were assessed.

Results The study included 102 patients, 94,1% females, age±SD 42.4±13.3 (range 20–73) years, disease duration±SD 93.9±77.1 (range 0,1–228) months. During fallow–up, 55 flares were enregistered, including 11 severe, with a SLEDAI increase with 3–17 points. The incidence of flares was 0,53 patient/year, the for severe flares - 0,10 patient/year. To assess the risk of flares, potential risk factors were studied (Table 1).

View this table:
Abstract 222 Table 1

The main risk factors were laboratory findings, while only active pulmonary involvement derived from SLAM and antiphospholipid syndrome, as clinical and laboratory variables, associated with the flares in SLE patients.

Conclusions In our study, the incidence of flare in a 12 moths period was 53,9%, including 10,8% of severe flares. We have determined that patients with high ERS, low Hb and lymphocytopenia are at risk for flares and antiphospholipid syndrome and pulmonary involvement were the main clinical risk factors in our cohort.

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