Background and aims Systemic lupus erythematosus (SLE) is a systemic connective tissue disease involving multiple organ systems. There is lack of data on clinical and immunolgical profile in SLE patients from Indian subcontinent.

Objectives To describe clinical profile, outcome and laboratory profile of 226 SLE patients from records maintained at a tertiary care centre in India from 2008 – 2016

Methods All patients who satisfied 1997 revised criteria of the ACR or the 2012 New SLICC Classification Criteria for SLE were included in the analysis. The medical records were analysed for clinical and laboratory profile of SLE patients.

Results A total of 226 SLE patients records were analysed. The female to male ratio was 9:1 (204 females, 22 males). The mean follow up was 4.2 years(Range 2–8 years). The overall mean age at diagnosis was 27 years (range 15–46 years). The most common clinical manifestations at onset were fatigue (78.4%), Anaemia (72.2%), polyarthralgia (66.2%), photosensitivity (61.1%), low grade fever (56.6%) and myalgias (52.1%). Renal involvement was seen in 56.3% subjects. ANA by immunofluorescence was positive in 100% and most common pattern was speckled (62.1%). Immunoblot assay for sub autoantibodies showed Anti DsDNA (56.7%), Antinucleosome (25.6%), antihistones (28.4%), anti SmD1 (28.2%), anti Ro52 Kd (58.4%) and Anti Ro 60 kd(52.2%). A total of 08 patients died during follow up and most common cause was sepsis with underlying renal involvement.

Conclusions This retrospective study on a large cohort of SLE patients from India shows significant difference in clinical manifestations and autoantibody profile in Asians as compared to Caucasians.