Article Text

PDF

260 The effect of vitamin d3 supplementation on the disease activities and degree of fatique in sle patients with hypovitamin d
  1. CS Wahono1,
  2. H Susianti2,
  3. A Rifai1,
  4. K Handono2 and
  5. H Kalim1
  1. 1Faculty of Medicine Brawijaya University/Dr. Saiful Anwar General Hospital, Internal Medicine, Malang, Indonesia
  2. 2Faculty of Medicine Brawijaya University/Dr. Saiful Anwar General Hospital, Clinical Pathology, Malang, Indonesia

Abstract

Background and aims Vitamin D has important roles in the regulation of the immune system in Lupus. 71% of lupus patients experienced hypovitamin D in Indonesia,. This study was aimed to determine the effect of vitamin D supplementation on the degree of disease activity and degree of fatigue in SLE patients with hypovitamin D.

Methods Thirty nine SLE patients with hypovitamin D were studied, that randomised into two groups: 20 patients was given vitamin D and 19 patients received placebo for 3 months. Disease activity is determined by the SLEDAI scores and the degree of fatigue is determined by the FSS (Fatigue Severity Scale).

Results This study showed that supplementation of vitamin D 1200 IU per day increased 6:55±1:27 ng/cc of 25 (OH) D. The decreased of SLEDAI scores in the supplementation group were greater than the placebo group (6.45±3:07 vs 0.17±1.63), p=0.000. The decreased of Fatigue Severity Scale in the supplementation group also greater than the placebo group (2.27±0.73 vs 0.005±0.62.), p=0.000.

Conclusions Vitamin D supplementation plays a role on improving the activity of the disease (SLEDAI score) and the condition of fatigue (FSS) in SLE patients with hypovitamin D.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.