Background and Aims The indirect immunofluorescence (IIF) pattern in ANA test provides initial assessment of autoantibody responses in candidate patients at risk of developing SLE. The International Consensus on ANA Patterns (ICAP) Initiative workshop originated in 2014, followed by the 2nd and 3rd workshops in 2015 and 2016. The goal of ICAP is to provide guidelines for ANA interpretation, thereby optimising adoption in diagnostic laboratories and extended to patient care.
Methods A working committee addressed collective issues on ANA nomenclature that are raised by participants representing research, clinical, and diagnostic laboratories.
Results ANA patterns are separated into three major categories (nuclear, cytoplasmic, and mitotic patterns). A total of 28 patterns were defined, described in detail, designated with alpha-numeric codes (AC-1 to AC-28), and summarised under a nomenclature and classification tree (ANApatterns.org). ICAP initiatives include translation of the website into other languages, establishing guidelines in ANA reporting, and programs for continuing education. The translation initiative promotes the establishment and dynamic engagement of a worldwide network. To date, the website displays its content in English, Spanish, Portuguese, Italian and German, while Chinese, Japanese, French, and Greek translations are ongoing. ICAP has provided a common platform to address issues that are of great interest to the scientific community. The establishment of a consensus on ANA reporting will require interaction with committees in charge of establishing disease classification and diagnostic criteria.
Conclusions Future goals include building collaborative data on ANA patterns, establishing new consensus patterns, and developing an interpretative description for each pattern for their widespread clinical use.
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