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297 Hyperprolactinaemia association with lupus nephritis disease activity
  1. MS Mohamed Said1,
  2. WA Wan Zaidi1,
  3. WY Kong1,
  4. A Abd Wahab2,
  5. H Othman2,
  6. N Abd Wahab1 and
  7. A Mohd Tamil3
  1. 1Universiti Kebangsaan Malaysia Medical Centre, Medical, Kuala Lumpur, Malaysia
  2. 2Universiti Kebangsaan Malaysia Medical Centre, Microbiology and Immunology, Kuala Lumpur, Malaysia
  3. 3Universiti Kebangsaan Malaysia Medical Centre, Community Health, Kuala Lumpur, Malaysia

Abstract

Background and aims Prolactin has been found to be associated with immune regulation in SLE. The aim of this study is to determine the correlation between high prolactin level in comparison with IL – 6 with lupus nephritis disease activity in UKMMC.

Methods In this cross-sectional study, the analysis was conducted in SLE patients who attended Nephrology clinic in UKMMC from August 2015 till February 2016

Results Out of 43 patients with lupus nephritis, 27.9% of the patients had raised serum prolactin. The median of serum prolactin level at 0 min was 19.91 ng/ml (IQR: 15.95–22.65 ) for active lupus nephritis that was significantly higher as compared to the median of serum prolactin level 14.34 ng/ml (IQR: 11.09–18.70 ) for patients in remission (p=0.014). The serum prolactin level was positively correlated to SLEDAI (rhos : 0.449, p=0.003 ) and UPCI level in lupus nephritis patients (rhos : 0.241, p=0.032). Assessment of serum IL-6 levels found that the active lupus nephritis patients were having a higher median level of 65.91 pg/ml (21.96–146.14) compared to in remission level of 15.84 pg/ml (IQR: 8.38–92.84), (p=0.039). ROC curve analysis of serum prolactin 0 min and serum prolactin 30 min and IL-6 level for prediction of SLE diseases activity provide the cutoff value of serum prolactin 0 min was 14.63 ng/ml with sensitivity 91.7% and specificity 58.1% and AUC of 0.74 (p=0.015).

Conclusions Baseline fasting serum prolactin level was found to be a sensitive biomarker for evaluation of lupus nephritis disease activity.

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