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316 The level of cd64 expression on monocyte correlates with the activity of lupus nephritis
  1. T Shimizu1,
  2. S Tsuji1,
  3. A Kikuchi-Taura2,
  4. E Oguro1,
  5. Y Okita1,
  6. M Shigesaka1,
  7. H Matsuoka1,
  8. T Nii1,
  9. S Teshigawara1,
  10. E Kudo-Tanaka1,
  11. Y Harada1,
  12. M Matsushita1,
  13. S Ohshima2,
  14. J Hashimoto1 and
  15. Y Saeki2
  1. 1Osaka Minami Medical Centre, Rheumatology and Allergology, Kawachinagano, Japan
  2. 2Osaka Minami Medical Centre, Clinical Research, Kawachinagano, Japan

Abstract

Background and aims Lupus nephritis (LN) is one of the most serious clinical manifestations of systemic lupus erythematosus (SLE). Recently, we have reported that the expression levels of CD64 on monocyte (mCD64), a high-affinity receptor for IgG (FcgRI), correlate with the disease activity of SLE (Lupus 2015;24:1076–80). However, the relation between lupus nephritis (LN) and mCD64 expression is yet to be elucidated. The aim of this study is to investigate whether or not mCD64 expression level correlates with the activity of LN.

Methods We quantitatively measured the mCD64 expression levels by flow cytometry in eight SLE patients with biopsy proven LN before and after treatment. All patients fulfilled the 1997 American College of Rheumatology classification criteria for SLE. The mCD64 expression levels of the individual patients were measured both at active (presence of proteinuria >0.5 g/day and/or active urinary sediment) and inactive phase (absence of proteinuria and active urinary sediment). The changes were analysed statistically (Wilcoxon signed-rank test).

Results The mean±SD of mCD64 expression levels before and after treatment were 42 463±15 466 and 19 190±1696 molecules/cell, respectively (p<0.01, Wilcoxon signed-rank test). The mCD64 expression levels in active LN was significantly higher than in inactive LN.

Conclusions The mCD64 expression level correlates with the activity of LN, although a larger scale study is needed to confirm the results.

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