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353 Coffee consumption and clinical outcomes in colombian patients with systemic lupus erythematosus
  1. MA Alzate2,
  2. F Ochoa1,
  3. P Ortiz-Salazar1,
  4. D Hernandez-Parra1 and
  5. R Pineda1
  1. 1ARTMEDICA, Clinical information group, Medellín, Colombia
  2. 2Universidad CES, Public Health Group, Medellin, Colombia

Abstract

Background and aims This study was performed to analyse the influence of coffee consumption on clinical outcomes in colombian patients with systemic lupus erythematosus (SLE).

Methods A cross-sectional analytical study was conducted in 731 Colombian patients with SLE in whom coffee consumption and its frequency was assessed. Differences in clinical outcomes (i.e., cardiovascular disease, age-at-onset, organ damage, polyautoimmunity, acute activity determined by SLEDAI, and clinical remission) were determined between drinkers and non-drinkers, as well as by frequency of consumption. Association was examined by chi-square and multivariate regression analyses.

Results Sociodemographic and clinical characteristics of the patients are shown in table 1. Out of a total of 731 patients, 70% were current coffee drinkers, 57% reported daily consumption, 10% weekly consumption and 3% monthly consumption. Coffee intake was found to be associated with SLE age at onset, cardiovascular disease and 6 months clinical remission (Table 2). According to the frequency of intake, daily consumption was associated to reduced risk of early age-at-onset and a positive association with 6 months clinical remission (OR: 0,45 95% CI 0,25–0,81 and OR: 1,55 95% CI 1,07–2,25, respectively). No differences were found for organ damage, polyautoimmunity and acute SLE activity.

Abstract 353 Table 1
Abstract 353 Table 1

Sociodemographic and clinical characteristics of the SLE patients

Abstract 353 Table 2
Abstract 353 Table 2

Association between coffee consumption and clinical outcomes in SLE patients (N=731)

Conclusions In Colombian SLE patients with coffee consumption, a reduced risk of early age-at-onset and cardiovascular disease was recognised. Also, a positive association with 6 month clinical remission was found. Due to the methodology of the study and its limitations, it is not possible to conclude a causal relationship. More studies must be done to clarify the influence of coffee in autoinmune disease.

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