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408 Analysis of influencing factors on quality of life of patients with sle
  1. F Zeng,
  2. Q Xu,
  3. D Liu,
  4. G Deng,
  5. H Luo,
  6. X Zuo and
  7. Y Li
  1. Xiangya hospital – Central South University, Department of Rheumatology and Immunology, Changsha, China

Abstract

Background and aims To investigate the influencing factors of quality of life (QOL) of patients with systemic lupus erythematosus (SLE).

Methods QOL of 104 SLE patients were investigated by SF-36 scale (Chinese version). Depression, anxiety, social support, sleep quality and fatigue were evaluated by PHQ-9, GAD-7, social support rating scale (SSRS), Pittsburgh sleep quality index (PSQI) and VAS respectively. The demographic and clinical data were also recorded. SLE disease activity was assessed by SLEDAI.

Results In SF-36 scale, scores of SLE patients were lower than normal people in global score and in all dimensionalities (p<0.05). SLEDAI, PHQ-9, GAD-7, PQSI and fatigue correlated negatively with SF-36 scores (p<0.01). SSRS correlated positively with SF-36 scores (p<0.01). In binary logistic regression analyses, disease activity, anxiety, social support, sleep quality and fatigue were the independent determinants of QOL in SLE (R2 =0.860, p<0.01).

Conclusions QOL of SLE patients are lower than normal people. Disease activity, anxiety, social support, sleep quality and fatigue are the major influencing factors of QOL in SLE.

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