Background and aims To compare specific health-related quality of life (HR-QoL) questionnaire (SLE-QoL) with a generic HRQoL questionnaire (SF-36) and to examine their sensitivity to changes defined by the global rating for change (GRC).
Methods Patients attending a single-centre lupus clinic in Thailand completed both validated SLE-QoL and SF-36 questionnaires, and rated their global change in QoL compared to previous visit using a 7-point Likert scale (GRC). Patients were grouped into either ‘no change’ (control group), ‘deterioration’ or ‘improvement’ categories (GRC status). Physician global assessment (PGA, 0–3) scores were collected for clinician-assessed disease activity. Associations between GRC status and SLE-QoL/SF-36 scores were examined using generalised estimating equations. Cohen’s d effect sizes were estimated to compare mean changes in SLE-QoL and SF-36 scores.
Results The analysis included 248 patients with 1265 visits. Patients reported improvement in ˜59%, deterioration in ˜16% and no change in QoL in ˜25% of visits. PGA demonstrated statistically significant (p<0.01), negative correlations with GRC (r=−0.49), SLE-QOL (r=−0.49), SF-36PCS (r=−0.50) and SF-36MCS (r=−0.36) scores. In contrast, SLE-QoL scores correlated positively and significantly (p<0.01) with SF-36PCS (r=0.56) and SF-36MCS (r=0.60) scores. Compared to control group, mean scores of SF-36PCS, SF-36MCS and SLE-QoL surveys were significantly lower in the deterioration group (mean change –4.96,–3.21, and −6.51, respectively, p<0.01) but SF-36PCS and SLE-QoL were significantly higher in the improvement group (mean change 1.22 and 1.35 respectively, p<0.01). Cohen’s d effect sizes were similar for both questionnaires.
Conclusions Both SLE-QoL and SF-36 demonstrated similar, strong associations with GRC-based deterioration or improvement.
- © 2017, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.