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458 Increased adhesion molecule levels in systemic lupus erythematosus: relationships with severity of illness, autoimmunity and cortisol levels
  1. A Name Colado Simão1,
  2. L Flor da Rosa Santos Silva2,
  3. MA Batisti Lozovoy1,
  4. B Miglioranza Scavuzzi3,
  5. N Perugini Stadtlober2,
  6. T Veiga Mayumi Iriyoda4,
  7. EM Vissoci Reiche1,
  8. I Dichi5,
  9. M Maes6,
  10. ER Delicato de Almeida1 and
  11. H Kaminami Morimoto1
  1. 1University of Londrina, Department of Pathology- Clinical Analysis and Toxicology, Londrina, Brazil
  2. 2University of Londrina, Biological Science, Londrina, Brazil
  3. 3University of Londrina, Health Science, Londrina, Brazil
  4. 4University of Londrina, Rheumatology, Londrina, Brazil
  5. 5University of Londrina, Department of Internal Medicine, Londrina, Brazil
  6. 6Deakin University, IMPACT Strategic Research Centre- School of Medicine, Geelong, Australia

Abstract

Background and aims To delineate disorders in adhesion molecules in systemic lupus erythematosus (SLE) and to assess whether cortisol, nuclear autoantibody (ANA) titers and the metabolic syndrome (MetS) are associated with adhesion molecules in SLE.

Methods 48 healthy individuals and 171 SLE patients were enrolled. Disease activity was determined by SLEDAI (SLE Disease Activity Index) score. Adhesion molecules and cortisol levels were evaluated.

Results Platelet endothelial cell adhesion molecule 1 (PECAM-1), Vascular cell adhesion molecule 1 (VCAM-1), E-selectin, P-selectin and Plasminogen activator inhibitor type-1 (PAI-1) were significantly higher in SLE patients. These significant differences could not be explained by the drug treatment. Mycophenolate treatment significantly decreased intercellular adhesion molecule 1 (ICAM-1) and increased E-selectin levels. Binary logistic regression analysis showed that PECAM-1 and PAI-1 predicted SLE with a sensitivity of 86.5% and a specificity of 81.3%. ANA was significantly and positively associated with PECAM-1, VCAM-1, E-selectin, and PAI-1, whilst cortisol was negatively associated with PCAM-1 and ICAM-1. There were significant associations between MetS and E-selectin and PAI-1. 18.2% of the variance in SLEDAI score was explained by increased PECAM-1 values and DNA titers and the MetS.

Conclusions Our data confirm that adhesion molecules play a role in the pathophysiology of SLE and show that increased adhesion molecule levels, especially PECAM-1, can be used as an external validating criterion for the diagnosis SLE. MetS, ANA, and cortisol modulate the adhesion molecule concentrations but do not explain the increased levels in SLE Increased levels of adhesion molecules are a new drug target in SLE.

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