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66 Antiphospholipid syndrome – cinical and immunological correlations and atherosclerosis
  1. N Stoilov,
  2. V Boyadzhieva and
  3. R Rashkov
  1. University hospital “St. Ivan Rilski”, Clinic of Rheumatology, Sofia, Bulgaria

Abstract

Background and aims In recent years, it is found that role in atherogenesis plays inflammatory component of immune response. In recent years found unarguably data for accelerated development of atherosclerotic plaques in patients with APS.

Our aim is to investigate the frequency of cardiovascular events and atherosclerosis in patients with primary and secondary antiphospholipid syndrome compared to healthy individuals and patients with systemic lupus erythematosus without antiphospholipid antibodies.

Methods We studied 99 patients with APS, 13 SLE and 32 healthy controls. They were tested for aPL antibodies (aCL,anti-b2gp1, anti-prothrombin), ANA-screen, ANA - profile and standart laboratory.

We examine Intima-Media thickness of carotit arteries and Calcium score of: a. coronaria sinister, a. anterior descendens sinister, a. circumflexa sinister, a. coronaria dexter, Aorta, Valvaorte to validate the atheroslerosis.

Results We found strong, statistically significant correlation between aCL antibodies and the presence of plaques in the left common carotid artery (p=0.041) and absent a correlation between aPL titers and presence of carotid plaques. In the group with APS, 33,3% (14) establishes a positive calcium score of coronary artheries, 11.9% (5) positive for aorta, Aortic valve Absent deposits, In the control group positive calcium score is one person (5.88%).

Conclusions It was established the relationship of antiphospholipid syndrome with the process of atherosclerosis.

The presence of atherosclerotic plaques is not associated with traditional risk factors.

Not establish a connexion between antiphospholipid antibodies and IMT.

Proven connexion between aCL and carotid plaques.

Not establish correlation between aPL and Ca score.

Persons with APS have a higher incidence of Calcium score versus healthy controls.

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