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77 Vitamin d deficiency is associated with disability in multiple sclerosis patients independently of oxidative and nitrosative stress
  1. S Oliveira1,
  2. D Frizon Alfieri2,
  3. A Simão3,
  4. L Mezzaroba1,
  5. AP Kallaur2,
  6. T Flauzino2,
  7. I Dichi4,
  8. M Alysson B Lozovoy1,
  9. B Sardinha Sabino5,
  10. K Panichi Zanin Ferreira6,
  11. W LCJ Pereira6,
  12. DR Kaimen-Maciel7 and
  13. EM Vissoci Reiche8
  1. 1State University of Londrina, Department of Pathology- Clinical Analysis and Toxicology- Health Sciences Centre, Londrina, Brazil
  2. 2State University of Londrina, Postgraduate Program- Health Sciences Centre, Londrina, Brazil
  3. 3Universidade Estadual de Londrina, Department of Pathology, Clinical Analysis and Toxicology, Londrina, Brazil
  4. 4State University of Londrina, Department of Clinical Medicine- Health Sciences Centre, Londrina, Brazil
  5. 5State University of Londrina, Pharmacy School- Health Sciences Center- State University of Londrina, Londrina, Brazil
  6. 6State University of Londrina, Postgraduate Program- Health Sciences Center- State University of Londrina, Londrina, Brazil
  7. 7State University of Londrina, 3Department of Clinical Medicine- Health Sciences Center- State University of Londrina- Londrina- Paraná- Brazil-, Londrina, Brazil
  8. 8State University of Londrina, Department of Pathology- Clinical Analysis and Toxicology- Health Sciences Center- State University of Londrina- Londrina- Paraná- Brazil, Londrina, Brazil

Abstract

Background and aims The aim of this study was to assess vitamin D status in patients with multiple sclerosis (MS) and to evaluate whether it was associated with oxidative and nitrosative stress (O and NS) markers and disability.

Methods This study included 137 patients with MS and 218 healthy controls. The markers evaluated were serum levels of 25-hydroxyvitamin D, lipid hydroperoxides, advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), and total radical-trapping antioxidant parameter TRAP/UA.

Results MS patients presented higher age (p<0.0001), and lower 25(OH)D (p=0.002), NOx, and TRAP/UA (<0.0001) than controls. When the age was used as an additional explanatory variable in binary logistic regression analyses, 25(OH)D, NOx, and TRAP/UA remained significant (p=0.016, p<0.0001, and p=0.002, respectively). Patients with 25(OH)D<20 ng/mL showed higher EDSS (p=0.016) and lower AOPP (p=0.046) than those with 25(OH)D≥20 ng/mL. After the binary logistic regression analyses, EDSS remained significantly associated with vitamin D deficiency. We showed that lower levels of 25(OH) were associated with higher EDSS independently of variables such as O and NS (AOPP and NOx), age, sex, body mass index, ethnicity, disease duration, MS therapy, use of interferon beta, and clinical forms of MS (odds ratio: 1.380, 95% confidence interval 1.030–1.843, p=0.031). Moreover, the study showed an association between serum levels of 25(OH)D and EDSS (r2=0.115, p=0.002), demonstrating that 25(OH)D may contributed with 11.5% of increase in EDSS.

Conclusions Our results suggest that vitamin D deficiency may be considered one of the predictors of the disability in MS patients, independently of their redox status.

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