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99 Hyper-activation and in situ recruitment of inflammatory vδ2 t cells contributes to disease pathogenesis in systemic lupus erythematosus
  1. W Mo,
  2. S Yin and
  3. X Zhang
  1. Beijing peking union medical college hospital, rheumatology, Beijing, China

Abstract

Background and aims Vδ2 T cells have predominantly been investigated in tumour immuno-surveillance and the host defense against viral invasion. The precise role of Vδ2 T cells in the pathogenesis of SLE remains elusive.

Methods We measured the proportion of peripheral Vδ2 T cells as well as the status and chemokine receptor expression profiles in SLE patients and healthy control (HC). In addition, Vδ2 T cell infiltration in the kidneys of patients with lupus nephritis was examined.

Results The percentage of peripheral Vδ2 T cells in new-onset SLE was decreased, and negatively correlated with the SLE Disease Activity Index score and the severity of proteinuria. These cells had a decreased apoptosis but an increased proliferation, and they showed increased accumulation in SLE kidneys. Moreover, IL-21 production and CD40L, CCR4, CCR7, CCR8, CXCR1 and CX3CR1 expression in Vδ2 T cells from SLE patients was significantly higher than from HC (p<0.05), and these factors were down-regulated in association with the repopulation of peripheral Vδ2 T cells in patients who were in remission (p<0.05). In addition, anti-TCR Vδ2 antibodies activation significantly upregulated these chemokine receptors on Vδ2 T cells from HC, and this effect was blocked by inhibitors of PLC-γ1, MAPK/Erk, and PI3K signalling pathways.

Conclusions The distribution and function status of Vδ2 T cells from SLE patients are abnormal, and these aberrations may contribute to disease pathogenesis.

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