Background and Aims Cytomegalovirus (CMV) infection at first presentation in paediatric SLE (pSLE) is a rare phenomenon.
Aim- To report an adolescent girl with SLE presenting with neurological and hepatic manifestations and CMV co- infection.
Methods A 12 year old girl presented with history of fever, maculopapular rash over the trunk, malar rash and jaundice. She had altered behaviour with agitation, disorientation, fluctuating consciousness, hallucinations, and altered sleep. On examination, she had malar rash, icterus, and hepatosplenomegaly. She also had catatonia, mutism, would stare intermittently, had low speech output and psychomotor retardation with rigidity. There was no focal deficit. Investigations revealed pancytopenia, transaminitis, conjugated hyperbilirubinemia, normal renal functions, antinuclear antibody (ANA) - positive (homogenous pattern), high anti-dsDNA with hypocomplementemia.Liver biopsy revealed steatosis with hepatitis. Screen for infections was negative, except CMV. Very high levels of CMV DNA in blood were noted on PCR. It was a clinical dilemma as to whether CMV was causative, co-infection or a re-activation due to immunosuppression. Magnetic resonance imaging (MRI) brain showed cortical atrophy. There was no evidence of any vascular involvement.
She was treated with intravenous (IV) methylprednisolone, IV cyclophosphamide pulses and oral valganciclovir.
Results A repeat CMV viral load done after six weeks of oral valganciclovir therapy was undetectable. She has been followed up for a period of 6 months. She has shown marked improvement in her neurological status and transaminases have normalised.
Conclusions CMV is an important pathogen in patients with SLE; however its exact pathogenesis needs more research.
- © 2017, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.