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163 Association between hypertension and proteinuria in systemic lupus erythematosus
  1. VN Moenardi1,
  2. BS Suryajaya,
  3. I I Hidayat1 and
  4. L Hamijoyo2
  1. 1Faculty of Medicine Universitas Padjadjaran, Immunology Study Group, Bandung, Indonesia
  2. 2Faculty of Medicine Universitas Padjadjaran, Department of Internal Medicine, Bandung, Indonesia

Abstract

Background and aims Hypertension is one of the most common comorbidities in patients with systemic lupus erythematosus (SLE). We aim to determine the association between hypertension, proteinuria, and elevated serum creatinine level in SLE.

Methods This is a cross sectional study of SLE patients who attended Rheumatology Clinic at Hasan Sadikin Hospital Bandung. Patients were diagnosed with SLE according to American College of Rheumatology (ACR) revised criteria 1997 and/or Systemic Lupus International Collaborating Clinics (SLICC) criteria 2012. High blood pressure (≥140/90/90 mmHg), proteinuria, and elevated serum creatinine level (≥1.6 mg/dL for men, ≥1.4 mg/dL for women) were identified from medical record. This study used the data in time the patients were diagnosed. The data of SLE patients from 2008 to 2016 were recorded in RSHS Lupus Registry. Chi-square analyses was performed to determine the association between those variabels.

Results A total of 428 SLE patients had a median age of 35 years (97.9% female), 64 of them (15%) were hypertensive, 176 SLE patients (41.1%) had proteinuria, and 106 SLE patients (24.8%) had elevated serum creatinine level. Forty one SLE patients with hypertension (64.1%) had proteinuria. Hypertension was associated with proteinuria in SLE patients (95% CI, Pearson Chi-Square 18.948, asymptotic significance <0.001). Elevated serum creatinine level had no association with hypertension (95% CI, Pearson Chi-Square 0.071, asymptotic significance 0.789) and with proteinuria (95% CI, Pearson Chi-Square 0.603, asymptotic significance 0.438).

Conclusions In this study, hypertension is associated with proteinuria. There are no associations between hypertension and proteinuria with elevated serum creatinine level.

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