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170 The clinical and laboratory features of patients with systemic lupus erythematosus in kyrgyzstan
  1. G Koilubaeva1,
  2. G Koilubaeva1,
  3. T Reshetnyak2,
  4. E Aseeva2,
  5. S Soloviev2,
  6. E Nasonov2,
  7. A Djumagulova1,
  8. V Eralieva1 and
  9. E Karimova1
  1. 1National Centre of Cardiology and Internal Medicine, Rheumatology, Bishkek, Kyrgyzstan
  2. 2Institute of Rheumatology at Russian Academy of Medical Science, Rheumatology, Moscow, Russia

Abstract

Background and aims There are no data regarding the real-life picture of SLE in Kyrgyzstan.

Methods In a prospective observation included 325 patients with SLE, who were treated in NCCIM (2012 - 2016). Majority of these patients (301) were young women (median - 27 [25;41]), primarily Kyrgyz (284), with disease duration of 3 (median-3,0 [0.7;8.0]) years. Assessed SLEDAI 2K and SDI.

Results They were mostly patients with acute variant of SLE-129 (39.7%), 127 (39.08%) were with high and 86 (26.46%) with very high activity. Most of the patients - 283 (87.1%) were registered with immunological activity. In most cases of the desease were: skin lesions (97.23%), serous membrane lesions (65.54%) and kidney lesions (59.38%). The neurological symptoms was noted in 120 patients (36.92%): 99 of 120 patients (82.5%) had a significant CNS lesions; 32 patients of 99 (32.3%) had neuropsychiatric disorders, 27 of these patients had visual and auditory hallucinatory syndrome. Respiratory disorders occurred in 60 (18.46%) patients. The vast majority of these patients were with pulmonary arterial hypertension (46.66%). Acute lupus pneumonitis was detected in 23 (38.33%) patients. At the onset of the study, SDI was identified in 65 patients (20%). These were mainly patients with irreversible changes in the kidney (30,8%), associated with taking GC (27.7%).

Conclusions Acute onset of the disease (39.7%) was noted in most Kyrgyz patients. 97.23% of those ones with primary skin lesions, 65.54% with serous membrane lesions and 59.38% with kidney lesions, 39.92% patients had various neurological symptoms, 32.3% of these patients had serious neuropsychiatric disorders.

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