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176 Accrual of disease comorbidities over 8 years in a multicentre inception sle cohort
  1. M Urowitz1,
  2. D Gladman1,
  3. J Su2 and
  4. N Anderson2
  5. Systemic Lupus International Collaborating Clnics
  1. 1University of Toronto, Medicine, Toronto, Canada
  2. 2Toronto Western Hospital, Rheumatology, Toronto, Canada

Abstract

Background and aims The annual accrual of comorbidities in patients with SLE is not well described. We report the annual occurrence of these features in an inception cohort of patients with SLE.

Methods An international research network comprised of 33 centres from 11 countries has followed an inception cohort of SLE patients 2yearly according to a standardised protocol between 2000 and 2016. Of these, 717 patients followed for a minimum of 8 years constitute the study population. Comorbidities including atherosclerotic vascular events (AVEs), osteoporosis, osteonecrosis and diabetes are assessed using the SLICC/ACR Damage Index (SLICC/DI). AVEs are described and attributed on a specialised form. Diagnosis of an event is confirmed using standard clinical criteria, relevant laboratory data and imaging where appropriate. Descriptive statistics were used.

Results Of the 717 patients followed for at least 8 years, 90.2% were female, 47.3% were Caucasian, 13.8% were Black, 19.4% were Asian, 16.3% Hispanic and 3.2% other. Their mean age at enrolment was 34.2±13.1 years and SLEDAI-2K at enrolment was 4.17±4.49. The duration from diagnosis to enrolment was 5.9±4.4 months.

Abstract 176 Table 1
Abstract 176 Table 1

Cumulative SDI, AVEs, steoporosis, osteonecrosis and diabetes in the firest 8 years of follow-up (n=17).

Abstract 176 Table 2
Abstract 176 Table 2

Cumulative comorbidities by year in caucasians compared to all other ethnicities

Mean SDI gradually increases over 8 years. The accumulation of AVEs, osteoporosis, osteonecrosis and diabetes all increase progressively over an 8 year period. Caucasians accumulate AVEs and osteoporosis more frequently than all “other” ethnicities. In contrast, all “other” ethnicities accumulate osteonecrosis more frequently than Caucasians. All ethnicities accumulate diabetes at the same frequency.

Conclusions As expected disease damage and comorbidities in newly diagnosed patients increase over their first 8 years. Different ethnicities accumulate comorbidities at different rates.

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