Background and aims Disease activity increases risk of irreversible organ damage in SLE.
To understand the impact of disease activity (SELENA-SLEDAI) and proportion of time with a certain level of disease activity on risk of developing new organ damage (SLICC/SCR Damage Index (SDI) score).
Methods Cox Proportional hazard models were used to estimate the impact of disease activity as time-dependent variables on the risk of developing any new organ damage over time.
Results Patients (n=2199) were followed for an average of 6.2 years (mean age at cohort entry, 38.0 years; mean disease duration, 5.1 years). The most frequent types of organ damage occurring over time were ocular (cataract) and musculoskeletal (osteoporotic fractures). In Model 1, excluding the variable ”proportion of clinic visits with SLEDAI score >6,” age, and SDI score at cohort entry, SLEDAI score during follow-up and corticosteroid use during follow-up were significant predictors of risk of developing any new organ damage. When including the ”proportion of clinic visits with SLEDAI score >6” (Model 2), SLEDAI score during follow-up was no longer significant. in Model 3, excluding the time-dependent variable ”SLEDAI score during follow-up” from the model, the effect of “proportion of clinic visits with SLEDAI score >5 was slightly reduced but remained significant.
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