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211 The major roles of monocytes and their product tumourtumor necrosis factor alpha in the induction of skin inflammation triggered by intradermal lupus igg
  1. G Xu1,
  2. L Liu2 and
  3. GM Deng3
  1. 1Nanjing Medical University, Key Laboratory of Antibody Techniques of Ministry of Health, Nanjing, China
  2. 2Harvard Medical School, Beth Israel Deaconess Medical Centre, Boston, USA
  3. 3Nanjing, China

Abstract

Background and aims Skin injury is the second most common clinical manifestation in patients with systemic lupus erythematosus (SLE), but its pathogenesis has not been thoroughly elucidated.

Methods Based on skin deposition of IgG in SLE, we studied the features and mechanisms of intradermal IgG-induced skin inflammation

Results We found that skin inflammation appeared at 3 hour and peaked at 3 d after intradermal injection of lupus IgG. This phenomenon was related to the dose of injected IgG but not to systemic disease activity. The severity of skin inflammation induced by lupus IgG was significantly decreased in mice depleted of monocytes and in mice deficient in TNF-a but not in mice lacking mature lymphocytes. Furthermore, lupus IgG promoted the progression of monocyte differentiation to dendritic cells (DCs) and enhanced the expression of TNF-α. TNF-α was found to stimulate the IgG-induced maturation of DCs and played a major role in the proliferation and activation of keratinocytes.

Conclusions The results also indicate that the deposition of IgG in skin exerts an important role in the pathogenesis of skin injury in patients with SLE; therefore, blocking the IgG/FcR signalling pathway can be a therapeutic target in skin lesions of patients with SLE.

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