RT Journal Article SR Electronic T1 227 Prevalence of npsle in north-indian sle patients and its impact on quality of life JF Lupus Science & Medicine JO Lupus Sci & Med FD Lupus Foundation of America SP A104 OP A105 DO 10.1136/lupus-2017-000215.227 VO 4 IS Suppl 1 A1 H Muhammed A1 V Lal A1 V Dhir A1 MK Goyal YR 2017 UL http://lupus.bmj.com/content/4/Suppl_1/A104.abstract AB Background and aims To look at the prevalence of neuropsychiatric manifestations in patients with SLE and assess its impact on qolMethods We included consecutive patients with SLE above the age of 18 [(SLICC) 2012]. A diagnosis of an NP (neuropsychiatric) syndrome was made as per ACR 1999 definitions. Manifestations occurring at any point of time after the diagnosis of SLE were considered. Some modifications used were - headaches were included if >4 hours, mood disorders or anxiety was considered if the patient reported them to cause ‘significant distress or impairment in functioning’. Cognitive testing was done by using the mini-mental state examination (cut-off of 23). Testing for autonomic neuropathy only involved blood pressure response to standing (>=30/15 abnormal). Screening for neuropathy was done in only ¼ patients by NCS. Quality of life was assessed by EURO QOL 5D questionnaireResults This study included 101 patients of SLE. Among these, 33 patients had neuropsychiatric manifestations with a total of 42 events. The most common manifestation was headache (10) followed by anxiety disorder (5) and peripheral neuropathy (9). Other NPSLE syndromes observed in the study are seizure (4), cognitive dysfunction (4), depression (4), acute confusional state (2), autonomic disorder (2), movement disorder (1) and multiple mononeuropathy (1). Mann-whitney U test showed that there was statistically significant differences in self-care score (p=0.002), limitation of mobility score (p=0.001), pain score(p=0.005) between NPSLE vs no NPSLE.Abstract 227 Table 1 Comparison of basic descriptors among patients with and without NPSLEAbstract 227 Table 2 Prevelance of Neuropsychiatric manifestationsAbstract 227 Figure 1 Percentage of patients reporting problem in eachConclusions NP manifestations are common and lead to significant reduction in qol in North Indian SLE patients.