PT - JOURNAL ARTICLE AU - SA Hall AU - JK Allen AU - N Payas AU - JF Merola AU - N Franchimont AU - AB Dilley TI - 405 Temporal relationship of cutaneous lupus erythematosus and systemic lupus erythematosus: a large, retrospective cohort study AID - 10.1136/lupus-2017-000215.405 DP - 2017 Mar 01 TA - Lupus Science & Medicine PG - A186--A187 VI - 4 IP - Suppl 1 4099 - http://lupus.bmj.com/content/4/Suppl_1/A186.short 4100 - http://lupus.bmj.com/content/4/Suppl_1/A186.full SO - Lupus Sci & Med2017 Mar 01; 4 AB - Background and aims The proportion of systemic lupus erythematosus (SLE) patients with cutaneous manifestations is well characterised, but the proportion with only cutaneous lupus erythematosus (CLE) who later develop SLE is poorly understood. A fuller understanding of comorbid intersections including temporal sequence may advance knowledge regarding underlying pathogenesis. We conducted a retrospective cohort study of CLE nested in U.S. administrative data (2004–2014), in order to understand frequency and temporality of comorbid SLE.Methods The datasource was Clinformatics Datamart Multiplan, a U.S. insurance claims database containing ˜100 million lives. The universe of adult CLE patients with ≥2 claims of ICD-9 695.4 (DLE) was first identified. Secondly, five mutually exclusive cohorts were defined by presence and temporality of SLE (defined as ≥2 claims of ICD-9 710.0 [SLE]): 1) CLE , no prior/subsequent SLE; 2) CLE before SLE; 3) SLE before CLE; 4) CLE and SLE, temporality unclear; 5) CLE with <2 SLE claims.Results The universe contained 42 871 patients (Figure 1). Each cohort had >50 (range: 51.5–67.3) mean months of database observation time. Approximately one-third (27.4%) were “CLE only”, with no previous/subsequent SLE diagnosis (Cohort 1), while a further 10.3% had <2 SLE claims thus not meeting the SLE case definition (Cohort 5). Only 11% percent had CLE before SLE (Cohort 2). Elapsed mean time from CLE to SLE in Cohort 2 was 12.8 (median: 6) months.Abstract 405 Figure 1 Conclusions About a third of CLE patients identified by DLE ICD-9 coding appeared to never develop SLE during observation time. Our “real world” study adds to sparse evidence on this topic.