PT  - JOURNAL ARTICLE
AU  - Sasha Bernatsky
AU  - Héctor A Velásquez García
AU  - John J Spinelli
AU  - Patrick Gaffney
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AU  - Rosalind Ramsey-Goldman
AU  - Sophia S Wang
AU  - Hans-Olov Adami
AU  - Demetrius Albanes
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AU  - Nikolaus Becker
AU  - Yolanda Benavente
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AU  - Heiner Boeing
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AU  - Paige M Bracci
AU  - Paul Brennan
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AU  - Kenneth Offit
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AU  - Marco Rais
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AU  - Nathaniel Rothman
AU  - Gilles Salles
AU  - Gianluca Severi
AU  - Richard K Severson
AU  - Christine F Skibola
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AU  - Anthony Staines
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AU  - Anne Tjonneland
AU  - Jenny Turner
AU  - Claire M Vajdic
AU  - Roel C H Vermeulen
AU  - Joseph Vijai
AU  - Paolo Vineis
AU  - Jarmo Virtamo
AU  - Zhaoming Wang
AU  - Stephanie Weinstein
AU  - Thomas E Witzig
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AU  - Anne Zeleniuch-Jacquotte
AU  - Yawei Zhang
AU  - Tongzhang Zheng
AU  - Mariagrazia Zucca
AU  - Ann E Clarke
TI  - Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma
AID  - 10.1136/lupus-2016-000187
DP  - 2017 Oct 01
TA  - Lupus Science & Medicine
PG  - e000187
VI  - 4
IP  - 1
4099  - http://lupus.bmj.com/content/4/1/e000187.short
4100  - http://lupus.bmj.com/content/4/1/e000187.full
AB  - Objective Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL.Methods GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis.Results Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765.Conclusions These data suggest several plausible genetic links between DLBCL and SLE.