Body weights, autoantibodies, lymph node size, glomerular area, volume (water, curcumin and turmeric) consumed per day and histopathology (FS) in submandibular/parotid glands of MRL-lpr/lpr and MRL-MpJ provided water, CU or TU
| Panel A | |||
|---|---|---|---|
| Parameter | Water group | CU group | TU group |
| Volume consumed (mL/day) MRL-lpr/lpr | 13.02±2.33 | 11.2±0.34 | 16.32±2.98 |
| Weight (g) | |||
| MRL-MpJ | 35.65 | 34.41 | 33.84 |
| MRL-lpr/lpr | 35.05 | 37.65 | 33.91 |
| ANA (1:80) Third bleed; MRL-lpr | Strongly positive | Weakly positive | Negative |
| Anti-dsDNA Bleed 1; 1:100 MRL-lpr/lpr | Positive | Positive | Negative (till bleed 3) |
| Anti-Sm Bleed 1 MRL-lpr/lpr and MpJ | Positive | Negative | Negative |
| Anti-RNP Bleed 1 MRL-lpr/lpr and MpJ | Positive | Negative | Negative |
| Average LN weight (g) MRL-lpr/lpr Mean±SE | 2606±1147 | 742±331 | 385±68 |
| Days lived | 148 | 173 | 132 |
| Glomerular area, 50 random glomeruli (µm2) (MRL-lpr/lpr) | 393 549±84 769 | 355 777±93 340 | 336 688±47 170 |
| Panel B | |||
|---|---|---|---|
| Animal | Number of foci | Glandular area (mm2) (submandibular/parotid) | FS |
| lpr-water | 4 | 7.21 | FS≥1 |
| lpr-water | 9 | 25.05 | FS≥1 |
| lpr-water | 5 | 17.73 | FS≥1 |
| lpr-CU | 5 | 9 | FS≥1 |
| lpr-CU | 4 | 10.55 | FS≥1 |
| lpr-CU | 1 | 29.58 | FS<1 |
| lpr-CU | 6 | 14.28 | FS≥1 |
| lpr-CU | 0 | 5.1 | FS=0 |
| lpr-CU | 2 | 8 | FS≥1 |
| lpr-TU | 4 | 18.92 | FS<1 |
| lpr-TU | 1 | 4.75 | FS<1 |
| lpr-TU | 0 | 4.13 | FS=0 |
| lpr-TU | 0 | 15.72 | FS=0 |
Panel A: body weights, autoantibodies, lymph node size, glomerular area and volume (water, CU and TU) consumed per day in lpr-water, lpr-CU and lpr-TU or MpJ -water, MpJ-CU and MpJ-TU groups of mice. Values are given as means±SD for each group (except for LN weights, given as SE). Statistical analyses were done by Student's t test and the p-value was arrived at to assess the statistical significance of the changes observed. p<0.05 was considered to be significant. Panel B: FS for salivary gland lymphocytic infiltrates in lpr-water, lpr-CU and lpr-TU groups of mice. FS in some mice not obtained due to autolysis of tissue.
ANA, antinuclear antibodies; CU, curcumin; FS, focus score; LN, lymph node; RNP, ribonucleoprotein; TU, turmeric.