sIL7R>1042 pmol/mL | dsDNA Ab titres>50 U/mL | sIL7R>1042 pmol/mL and dsDNA Ab titres>50 U/mL | UPC>0.5 | sIL7R>1042 pmol/mL and UPC>0.5 | serum C3<85 mg/dL | sIL7R>1042 pmol/mL and serum C3<85 mg/dL | |
---|---|---|---|---|---|---|---|
True positive | 12 | 12 | 10 | 14 | 10 | 13 | 9 |
True negative | 59 | 55 | 69 | 65 | 71 | 41 | 67 |
False positive | 13 | 17 | 3 | 7 | 1 | 31 | 5 |
False negative | 4 | 4 | 6 | 2 | 6 | 3 | 7 |
Sensitivity (CI)—% | 75.0 (47.4 to 91.6) | 75.0 (47.4 to 91.7) | 62.5 (35.8 to 83.7) | 87.5 (60.4 to 97.8) | 62.5 (35.8 to 83.7) | 81.2 (53.7 to 95.0) | 56.2 (30.5 to 79.2) |
Specificity (CI)—% | 81.9 (70.7 to 89.7) | 76.4 (64.6 to 85.2) | 95.8 (87.5 to 98.9) | 90.3 (80.4 to 95.7) | 98.6 (91.5 to 99.9) | 56.9 (44.8 to 68.4) | 93.0 (83.7 to 97.4) |
Predictive positive value (CI)—% | 48.0 (28.3 to 68.2) | 41.4 (24.1 to 60.9) | 76.9 (46.0 to 93.8) | 66.7 (43.1 to 84.5) | 90.9 (57.1 to 99.5) | 29.5 (17.2 to 45.4) | 64.3 (35.6 to 86.0) |
Predictive negative value (CI) % | 93.6 (83.7 to 97.9) | 93.2 (82.7 to 97.8) | 92.0 (82.8 to 96.7) | 97.0 (88.7 to 99.4) | 92.2 (83.2 to 96.8) | 93.2 (80.3 to 98.2) | 90.5 (80.9 to 95.8) |
Positive likelihood ratio | 4.15 (2.35 to 7.32) | 3.18 (1.92 to 5.25) | 15 (4.65 to 48.4) | 9 (4.35 to 18.6) | 45 (6.2 to 327) | 1.89 (1.32 to 2.69) | 8.1 (3.13 to 20.9) |
Negative likelihood ratio | 0.30 (0.13 to 0.71) | 0.33 (0.14 to 0.77) | 0.39 (0.21 to 0.73) | 0.14 (0.04 to 0.51) | 0.38 (0.04 to 0.18) | 0.33 (0.12 to 0.93) | 0.47 (0.27 to 0.82) |
dsDNA, double-stranded DNA; sIL7R, soluble form of the interleukin-7 receptor; UPC, urinary protein to creatine.