Risk factors for OP and FFx
| No OP (134) | With OP (52) | With FF (22) | p Value | |
|---|---|---|---|---|
| Mean BMI | 23.8±6 kg/m2 | 23.2±3 kg/m2 | 23.7±3 kg/m2 | Ns |
| Former smoking | 26/134 (19.4%) | 9/52 (17.3%) | 2/22 (9%) | Ns |
| Current smoking | 25/134 (16.4%) | 8/52 (15.3%) | 3/22 (13.6%) | Ns |
| Postmenopausal status | 30/128 (23.4%) | 28/47 (59.6%) | 16/22 (72.7%) | 0.0001* |
| Thyroid disorders | 48/134 (35.8%) | 21/52 (40.4%) | 10/22 (45.5%) | Ns |
| Mean total dose of GC | 24.4±16.6 g | 37.1±25.5 g | 48.9±28.8 g | <0.001* |
| GC pulses | 85/134 (63.4%) | 28/52 (53.8%) | 14/22 (63.6%) | Ns |
| AC therapy | 24/134 (17.9%) | 13/52 (25%) | 10/22 (45.5%) | 0.003† |
| Mean duration | 7.5±5.2 years | 13.3±9.2 years | 14.4±9.7 years | 0.05* |
| Antiepileptic therapy | 7/134 (5.2%) | 10/52 (19.2%) | 6/22 (27.3%) | <0.01* |
| Mean duration | 9.7±7.8 years | 13.4±11.9 years | 11.5±6.4 years | Ns |
| CyA therapy | 38/134 (28.4%) | 10/52 (19.2%) | 4/22 (18.1%) | Ns |
*OP and FFx versus no OP.
†No OP- OP versus FFx.
AC, anticoagulants; BMI, body mass index; CyA, ciclosporin A; FFx, fragility fractures; GC, glucocorticoids; OP, osteoporosis.