Correlations of changes of serum biomarkers versus changes of cognitive performance over time (N=27)†
| S100-A8/9 | S100B | NGAL | aNR2-AB | |
|---|---|---|---|---|
| Formal neurocognitive testing | ||||
| Working memory | 0.44* | 0.07 | 0.26 | −0.59** |
| Processing speed | −0.06 | 0.03 | −0.46* | 0.22 |
| Attention | 0.16 | 0.16 | −0.16 | 0.00 |
| VCA | −0.02 | 0.12 | −0.11 | 0.12 |
| Ped-ANAM | ||||
| CDD | 0.15 | 0.48* | 0.10 | 0.05 |
| CS | 0.18 | 0.41* | 0.28 | −0.12 |
| CPT | 0.24 | 0.07 | −0.13 | −0.01 |
| Logical | 0.19 | 0.32 | 0.13 | 0.12 |
| M2S | 0.06 | 0.00 | 0.01 | 0.38* |
| MG | 0.15 | 0.30 | 0.33 | −0.21 |
| Math | 0.10 | 0.36 | 0.08 | 0.16 |
| Spatial | 0.40* | 0.44* | 0.30 | −0.25 |
| Memory | −0.01 | 0.44* | 0.08 | −0.17 |
| Overall | 0.29 | 0.46* | 0.15 | 0.06 |
*p Value <0.05. **p Value <0.01.
†Values are Pearson's correlation coefficients.
aNR2-AB, antibodies to NR2 glutamate receptor; NGAL, neutrophil gelatinase associated lipocalin; Ped-ANAM, Paediatric Automated Neuropsychological Assessment Metrics; Ped-ANAM Subtests: CDD, Code Substitution Delayed; CS: Code Substitution; CPT, Continuous Performance Test; Logical, logical relations; M2S, Matching to Sample; MG, matching grids; Math, mathematical processing; Spatial, spatial processing; Memory, Sternberg Memory Search; VCA, visuoconstructional ability.