Pearson's correlation coefficient† | OR (+SE)‡ | |||||||
---|---|---|---|---|---|---|---|---|
S100A8/A9 | S100B | NGAL | aNR2-AB | dsDNA-AB | aGP1-AB | aP-AB | LAC | |
Formal neurocognitive testing | ||||||||
Working memory | 0.14 | 0.02 | −0.06 | −0.23 | 0.023±0.46 | −0.324±0.46 | −1.281±0.61* | 0.297±0.53 |
Processing speed | −0.02 | 0.02 | −0.27* | 0.26* | 0.086±0.34 | 1.902±1.24 | −0.955±0.45* | −0.031±0.64 |
Attention | −0.03 | −0.05 | −0.21 | 0.12 | 0.095±0.30 | 0.142±0.31 | −0.487±0.31 | −0.151±0.29 |
VCA | −0.04 | −0.12 | −0.05 | 0.18 | −0.139±0.31 | −0.074±0.38 | −1.399±0.46** | 0.137±0.46 |
Ped-ANAM | ||||||||
CDD | 0.00 | −0.20 | 0.00 | 0.02 | 0.012±0.02 | −0.068±0.04* | −0.011±0.02 | −0.067±0.03** |
CS | −0.14 | −0.03 | 0.19 | −0.16 | 0.014±0.04 | −0.317±0.15* | −0.019±0.04 | −0.146±0.13 |
CPT | 0.12 | −0.05 | 0.14 | 0.14 | −0.010±0.01 | −0.031±0.02 | −0.020±0.01* | 0.013±0.02 |
Logical | −0.09 | −0.09 | 0.17 | −0.04 | 0.021±0.04 | −0.198±0.11* | 0.001±0.03 | −0.099±0.09 |
M2S | −0.01 | −0.11 | 0.19 | 0.11 | −0.013±0.01 | −0.042±0.03 | −0.017±0.02 | −0.021±0.02 |
MG | −0.09 | 0.10 | 0.16 | −0.21* | 0.029±0.03 | 0.034±0.09 | −0.006±0.02 | −0.011±0.06 |
Math | −0.28* | −0.05 | 0.06 | −0.19 | 0.009±0.04 | −0.092±0.06 | 0.003±0.04 | −0.231±0.10* |
Spatial | 0.07 | 0.00 | 0.14 | −0.09 | −0.034±0.03 | −0.064±0.08 | −0.024±0.03 | 0.000±0.08 |
Memory | 0.08 | 0.10 | 0.21 | −0.14 | −0.034±0.04 | −0.064±0.04 | −0.023±0.04 | −0.032±0.04 |
Overall | 0.06 | −0.01 | 0.20 | −0.01 | 0.000±0.00 | −0.017±0.01* | −0.003±0.00 | −0.009±0.01 |
*p<0.05.
**p<0.01.
†A correlation coefficient was estimated from the variance-covariance matrix from a mixed effect model after pooling data from two visits and adjusting for demographics.
‡A log (OR) was estimated from a logistic regression model after pooling data from two visits and adjusting for demographics.
Accuracy, percentage correctly answered questions per Ped-ANAM subtest; Ped-ANAM Subtests: CDD, Code Substitution Delayed; CS: Code Substitution; CPT, Continuous Performance Test; Logical, Logical Relations; M2S, Matching to Sample; MG, Matching Grids; Math, Mathematical Processing; Spatial, Spatial Processing; Memory, Sternberg Memory Search.
ds DNA-AB, anti-dsDNA antibodies; aGP1-AB, antiglycoprotein-1 antibodies; aNR2-AB, antibodies to NR2 glutamate receptor; aP-AB, antiribosomal P antibodies; LAC, lupus anticoagulant; NGAL, neutrophil gelatinase associated lipocalin; Ped-ANAM, Paediatric Automated Neuropsychological Assessment Metrics; VCA, visuoconstructional ability.