Clinical descriptors for all patients with SLE at study visit (n=92)
| Overall | VWF:Ag (Rs coefficient or median level) | VWF:RCo (Rs coefficient or median level) | VWF RCo/Ag ratio (Rs coefficient or median level) | |
|---|---|---|---|---|
| Age (years) | 49.9 (36–60) | 0.17 | 0.146 | −0.15 |
| Female gender | 81 (88%) | 141/153 | 120/112 | 0.8 |
| Disease duration (months) | 126 (61–213) | 0.13 | 0.06 | −0.13 |
| SLEDAI-2K | 6 (2–12) | 0.18 | −0.06 | 0.18 |
| SLICC-DI | 1 (0–2) | 0.11 | −0.04 | −0.25* |
| Prednisone dose (mg/d) | 5 (0–7.5) | 0.07 | 0.18 | −0.01 |
| BMI | 25 (22–28) | 0.25* | 0.13 | −0.1 |
| Diastolic blood pressure | 80 (68.5–85) | 0.12 | 0.06 | −0.15 |
| Renal disease | 45 (49%) | 133/143 | 116/126 | 0.82 |
| Vasculitis | 27 (29%) | 147/142 | 140/120 | 0.82 |
| Serositis | 21 (23%) | 164/142* | 140/120 | 0.83 |
| MI, stroke or thrombosis | 24 (26%) | 153/141 | 120/120 | 0.83 |
| aPL antibody presence | 37 (40%) | 141/142 | 120/126 | 0.81 |
| Hydroxychloroquine user | 56 (61%) | 139/149 | 120/140 | 0.84 |
| Immunosuppressant user | 32 (35%) | 138/140 | 120/126 | 0.82 |
| Aspirin/warfarin user | 31/8 (34%/9%) | 140/140 | 120/123 | 0.82 |
| Fish oil, regular user | 39 (43%) | 158/142 | 140/120 | 0.83 |
Overall figures represent absolute numbers (%) or median values (IQR) for the whole cohort. The association of each disease manifestation with VWF:Ag levels, VWF:RCo and VWF RCo/Ag ratio is given as Rs for continuous variables or as median levels for dichotomous variables.
*Statistically significant correlation observed in all patients or a significant difference in level compared with other patients not experiencing that disease manifestation (p<0.05).
Ag, antigen; aPL, antiphospholipid; BMI, body mass index; MI, myocardial infarction; RCo, ristocetin cofactor; Rs, Spearman rank correlation coefficients; SLEDAI-2K, Systemic Lupus Erythematous Disease Activity Index 2000; SLICC-DI, Systemic Lupus International Collaborative Clinics Damage Index; SLE, systemic lupus erythematous; VWF, von Willebrand factor.