Laboratory findings in all patients with SLE (n=92)
| Median levels | VWF:Ag Rs. | VWF:RCo Rs. | VWF RCo/Ag ratio Rs. | |
|---|---|---|---|---|
| Factor VIII | 149% (121–160)* | 0.56† | 0.53† | −0.02 |
| Fibrinogen | 3.5 (3.2–4.1) | 0.28‡ | 0.203 | −0.08 |
| ESR (mm/h) | 20 (10–33)* | 0.32† | 0.26‡ | 0.04 |
| CRP (mg/L) | 4.0 (4.0–4.0) | 0.13 | 0.136 | 0.03 |
| Hb (g/dL) | 13.0 (12.1–14.1) | 0.10 | −0.106 | −0.12 |
| WBC (×109/L) | 5.8 (4.3–7.1)* | −0.26‡ | −0.15 | −0.17 |
| Lymphocytes(×109/L) | 1.00 (1.00–2.00)* | 0.11 | 0.05 | −0.02 |
| NK cells | 0.10 (0.7–0.18) | 0.21‡ | 0.17 | −0.11 |
| B cells | 0.11 (0.04–0.25) | 0.06 | 0.04 | −0.04 |
| Platelets | 256 (217–295) | −0.1 | −0.11 | −0.02 |
| Albumen | 43 (41–45)* | 0.15 | −0.19 | −0.06 |
| Creatinine (mmol/L) | 63 (53–70) | 0.11 | 0.14 | −0.06 |
| Anti-dsDNA Ab (IU) | 120 (90–170)* | 0.27† | 0.26‡ | 0.05 |
| C3 | 0.95 (0.79–1.11) | 0.18 | 0.04 | −0.15 |
| Cholesterol | 4.6 (4.0–5.3) | 0.28† | 0.23‡ | −0.03 |
| IgG | 13.3 (10.9–16.3) | 0.33† | 0.171 | 0.04 |
| IL-6 (pg/mL) | 14 (14–19) | 0.06 | 0.12 | 0.27 |
| TNFα (pg/mL) | 34.3 (21–87) | 0.04 | 0.07 | 0.08 |
| BAFF (pg/mL) | 1740 (1280–2351)* | 0.08 | 0.19 | 0.15 |
| Prealbumin | 0.25 (0.22–0.29) | −0.07 | −0.06 | 0.08 |
| Ceruloplasmin | 0.32 (0.29–0.38) | 0.40† | 0.37† | 0.02 |
| TIBC | 59.5 (53.0–67.0) | −0.12 | −0.29‡ | −0.25‡ |
| Transferrin | 2.40 (2.10–2.65) | −0.14 | −0.32† | −0.23‡ |
Figures are given as median values (IQR) observed in the whole cohort and as the Spearman rank correlation coefficients (Rs) for the association between each serological marker and VWF:Ag levels, VWF:RCo and VWF RCo/Ag ratio.
*Statistically significant different level compared with healthy controls (p<0.05).
†Statistically significant correlation (p<0.01).
‡Statistically significant correlation (p<0.05).
Ag, antigen; BAFF, B-cell-activating factor; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; Hb, haemoglobin; IL, interleukin; NK cells, natural killer cells; RCo, ristocetin cofactor; Rs, Spearman rank correlation coefficients; SLE, systemic lupus erythematous; TIBC, total iron-binding capacity; TNF, tumour necrosis factor; VWF, von Willebrand Factor, WBC, white blood cell.