Odds ratios for adverse pregnancy outcome (n = 40) among 149 pregnancies
| Predictor | Number of occurrences | Univariable OR (95% CI ): | Model 1* OR (95% CI ): | Model 2# OR (95% CI ): |
|---|---|---|---|---|
| Organ-specific activity six months prior to conception | ||||
| Cytopenia | 17 | 2.6 (0.8 – 8.5) | 1.8 (0.5 – 6.0) | 1.6 (0.5 – 5.4) |
| Nephritis | 10 | 7.3 (1.5 – 35.2) | 4.6 (0.9 – 23.4) | 3.3 (0.6 – 17.9) |
| Skin disease | 15 | 1.0 (0.3 – 3.9) | 1.3 (0.4 – 5.0) | 1.2 (0.3 – 4.8) |
| Arthritis | 13 | 0.8 (0.2 – 3.6) | 0.7 (0.1 – 3.2) | 0.7 (0.1 – 3.0) |
| Serositis | 5 | 1.8 (0.2 – 14.1) | 1.6 (0.2 – 12.7) | 1.0 (0.1 – 7.8) |
| Organ-specific activity during pregnancy | ||||
| Cytopenia | 23 | 4.8 (1.7 – 13.9) | 4.2 (1.4 – 12.2) | 3.9 (1.3 – 11.4) |
| Nephritis | 16 | 4.4 (1.3 – 14.9) | 3.5 (1.0 – 12.2) ** | 3.6 (1.0 – 12.8) $ |
| Skin disease | 13 | 1.9 (0.5 – 7.1) | 1.3 (0.3 – 5.4) | 1.3 (0.3 – 5.2) |
| Arthritis | 8 | 3.2 (0.6 – 16.2) | 3.7 (0.8 – 18.5) | 3.9 (0.8 – 19.7) |
| Serositis | 8 | 4.8 (0.9 – 25.5) | 5.7 (1.1 – 30.3) | 5.9 (1.0 – 34.0) ++ |
Adverse pregnancy outcome: pre-eclampsia, preterm <37weeks, miscarriage (fetal loss at 12–20 weeks gestation), stillbirth (fetal loss at ≥20 weeks gestation), SLE-related elective terminationOR and 95% CI: from generalised linear mixed models to account for correlated data among 114 women carrying a total of 149 pregnancies
*Model 1: adjusted for ethnicity (Hispanic/non-Hispanic) and prior adverse pregnancy outcome
#Model 2: model 1 + corticosteroid and/or azathioprine use six months before conception, and hydroxychloroquine use six months before conception
**p = 0.046 pp = 0.045 ++p = 0.049