Comparison of the prevalence of early secondary amenorrhoea, ever being pregnant and ever having a child by cyclophosphamide status and whether the women experienced early menopause
| Experiencing early secondary amenorrhoea | Ever being pregnant | Ever having a child | |||||
|---|---|---|---|---|---|---|---|
| Crude PR (95% CI) | Adj. PR (95% CI)* | Crude PR (95% CI) | Adj. PR (95% CI)† | Crude PR (95% CI) | Adj. PR (95% CI)† | ||
| Ever treated with cyclophosphamide | Yes | 2.4 (1.3 to 4.4) | 2.3 (1.1 to 4.7) | 0.9 (0.7 to 1.1) | 0.8 (0.7 to 1.0) | 0.8 (0.6 to 1.1) | 0.8 (0.6 to 1.0) |
| No | Ref | Ref | Ref | Ref | Ref | Ref | |
| Experienced early secondary amenorrhoea | Yes | – | – | 0.8 (0.6 to 1.0) | 0.9 (0.8 to 1.1) | 0.7 (0.5 to 1.0) | 0.8 (0.6 to 1.1) |
| No | – | – | Ref | Ref | Ref | Ref | |
*A Poisson regression model with a robust variance was used and was adjusted for age at diagnosis, race, education level, income, marital status, current insurance and Brief Index of Lupus Damage score
†A Poisson regression model with a robust variance was used to estimate the effect of treatment with cyclophosphamide and was adjusted for age at diagnosis, race, education level, income, marital status, current insurance, and Brief Index of Lupus Damage score. A similar model was used to estimate the effect of early secondary amenorrhoea, but was also adjusted for treatment with cyclophosphamide.