Table 3

Linear mixed model estimates for the biomarkers and the eight domains of SF-36

Domain	EC4d (log net MFI)	EC3d (log net MFI)	ECR1 (log net MFI)	C3 (mg/dL)	C4 (mg/dL)	Anti dsDNA (units)	AntiC1q (units)
Physical function	−1.83±2.02 p=0.365	−1.01±1.54 p=0.513	3.43±2.21 p=0.121	−0.08±0.04 p=0.033	0.08±0.14 p=0.559	0.01±0.00 p=0.037	0.00±0.03 p=0.958
Role Physical	−6.96±2.00 p=0.001	−4.89±1.54 p=0.002	0.91±2.22 p=0.684	−0.06±0.04 p=0.148	0.13±0.14 p=0.358	0.01±0.01 p=0.101	−0.03±0.03 p=0.172
Bodily pain	−8.63±2.53 p=0.001	−6.34±1.94 p=0.001	1.98±2.9 p=0.495	−0.06±0.05 p=0.216	0.26±0.18 p=0.152	0±0.01 p=0.725	−0.02±0.03 p=0.562
General health	−6.64±1.3 p<0.001	−3.5±1.01 p=0.001	−1.57±1.45 p=0.280	−0.02±0.03 p=0.555	0.23±0.09 p=0.015	0.00±0.00 p=0.760	−0.01±0.02 p=0.594
Vitality	−5.81±1.67 p=0.001	−5.26±1.27 p<0.001	−0.59±1.85 p=0.748	0.02±0.03 p=0.502	0.22±0.12 p=0.058	0.00±0.00 p=0.765	−0.04±0.02 p=0.074
Social functioning	−8.44±2.14 p<0.001	−5.21±1.65 p=0.002	1.18±2.41 p=0.624	−0.03±0.04 p=0.461	0.16±0.15 p=0.313	0.01±0.01 p=0.151	−0.05±0.03 p=0.093
Role emotional	−4.5±2.22 p=0.043	−0.69±1.71 p=0.687	−3.85±2.44 p=0.116	−0.11±0.04 p=0.011	−0.24±0.16 p=0.127	0.01±0.01 p=0.247	−0.05±0.03 p=0.058
Mental Health	−6.72±1.47 p<0.001	−3.48±1.14 p=0.002	0.5±1.65 p=0.764	0.01±0.03 p=0.716	0.28±0.11 p=0.009	0.00±0.00 p=0.391	−0.05±0.02 p=0.005

Estimates with p values are given. EC4d, EC3d and ECR1 were log transformed as log net MFI.
MFI, mean fluorescent intensity; SF-36, short-form 36 questionnaires.