Frequency of CR1 genotypes and alleles found among HCs and Indian patients with SLE
| CR1 polymorphisms | Genotype or allele | HCs (n=300) | SLE (n=297) | p Value | OR (95% CI) |
|---|---|---|---|---|---|
| CR1 intron 27 (A>T) | Genotype | ||||
| rs11118133 | AA | 66 (22) | 60 (20) | 1 | Ref |
| AT | 154 (51) | 150 (50.5) | 0.75 | 1.07 (0.70 to 1.62) | |
| TT | 80 (27) | 87 (29.5) | 0.48 | 1.19 (0.75 to 1.90) | |
| Dominant | AT+TT | 234 (78) | 237 (80) | 0.61 | 1.11 (0.75 to 1.65) |
| Recessive | AA+AT | 220 (73) | 210 (70.5) | 1 | Ref |
| TT | 80 (27) | 87 (29.5) | 0.52 | 1.13 (0.79 to 1.62) | |
| Allele | |||||
| A | 286 (48) | 270 (45) | 1 | Ref | |
| T | 314 (52) | 324 (55) | 0.45 | 1.09 (0.87 to 1.37) | |
| CR1 exon 22 (A>G) | Genotype | ||||
| rs2274567 | AA | 46 (15) | 14 (5) | 1 | Ref |
| AG | 124 (41) | 114 (38) | 0.0007 | 3.02 (1.57 to 5.78) | |
| GG | 130 (44) | 169 (57) | 2.22E-6 | 4.27 (2.25 to 8.10) | |
| Dominant | AG+GG | 254 (85) | 283 (95) | 0.00001 | 3.66 (1.96 to 6.81) |
| Recessive | AA+AG | 170 (56) | 128 (43) | 1 | Ref |
| GG | 130 (44) | 169 (57) | 0.001 | 1.72 (1.24 to 2.38) | |
| Allele | |||||
| A | 216 (36) | 142 (24) | 1 | Ref | |
| G | 384 (64) | 452 (76) | 5.28E-6 | 1.79 (1.39 to 2.30) | |
| CR1 exon 33 | Genotype | ||||
| (G>C) | CC | 46 (15) | 20 (7) | 1 | Ref |
| rs3811381 | CG | 150 (50) | 104 (35) | 0.12 | 1.59 (0.89 to 2.85) |
| GG | 104 (35) | 173 (58) | 2.40E-6 | 3.82 (2.14 to 6.82) | |
| Dominant | CG+GG | 254 (85) | 277 (93) | 0.001 | 2.50 (1.44 to 4.35) |
| Recessive | CC+CG | 196 (65) | 124 (42) | 1 | Ref |
| GG | 104 (35) | 173 (58) | 0.0001 | 2.62 (1.88 to 3.66) | |
| Allele | |||||
| C | 242 (40) | 144 (24) | 1 | Ref | |
| G | 358 (60) | 450 (76) | 2.63E-9 | 2.11 (1.64 to 2.70) |
Bold indicates statistical significance.
Data are no. (%) of participants unless otherwise specified.
HC, healthy control; SLE, systemic lupus erythematosus.