Autoantibody specificities in Native American patients with SLE compared with other ethnicities
| Native American n=268 | African-American n=1074 | European American n=1567 | Hispanic n=239 | |
| ANA* n (%) | 260 (97) | 1038 (97) P=0.8503 | 1427 (91) P=0.0004 | 221 (92) P=0.0257 |
| Anti-dsDNA* n (%) | 90 (34) | 341 (32) P=0.5596 | 347 (22) P<0.0001 | 54 (23) P=0.0076 |
| Anti-Sm* n (%) | 15 (6) | 144 (13) P=0.0002 | 31 (2) P=0.0021 | 12 (5) P=0.8444 |
| Anti-nRNP* n (%) | 43 (16) | 396 (37) P<0.0001 | 140 (9) P=0.0008 | 40 (17) P=0.9044 |
| Anti-Ro/SSA* n (%) | 72 (27) | 262 (24) P=0.4297 | 268 (17) P=0.0002 | 52 (22) P=0.2142 |
| Anti-La/SSB* n (%) | 16 (6) | 51 (5) P=0.4328 | 80 (5) P=0.5527 | 16 (7) P=0.8552 |
| Antiribosomal P* n (%) | 5 (2) | 23 (2) P>0.9999 | 8 (1) P=0.0303 | 7 (3) P=0.5615 |
| Unidentified autoantigen* n (%) | 78 (41) | 206 (24) P=0.0006 | 227 (17) P<0.0001 | 44 (23) P=0.0050 |
| aCL (IgG)† n (%) | 93 (35) | 377 (35) P=0.9430 | 430 (27) P=0.0190 | 77 (32) P=0.5728 |
| aCL (IgM)† n (%) | 29 (11) | 55 (5) P=0.0011 | 163 (10) P=0.8292 | 31 (13) P=0.4925 |
Number and percentage of patients positive, and P values are shown. Differences in autoantibody specificities were analysed using Fisher’s exact test. Bold P values are significant compared with the Native American group.
*These autoantibody specificities were determined by IIF.
†These autoantibody specificities were determined by ELISA.
aCL, anticardiolipin; dsDNA, double-stranded DNA; IIF, indirect immunofluorescence; SLE, systemic lupus erythematosus.