Table 1

Anifrolumab potently inhibits ISRE signalling induced by 100 IU/mL of human recombinant type I IFNs in a luciferase reporter cell assay

Type I IFN subtypeIC50 (nM)
IFN-α10.004±0.01
IFN-α20.3±0.02
IFN-α40.004±0.01
IFN-α50.01±0.01
IFN-α60.04±0.01
IFN-α70.04±0.02
IFN-α80.03±0.04
IFN-α100.01±0.01
IFN-α140.02±0.01
IFN-α160.02±0.03
IFN-α170.04±0.03
IFN-α210.01±0.002
IFN-β10.03±0.025
IFN-ω0.07±0.03
  • Data represent means ±SD deviations from three to five individual experiments.

  • IC50, half-maximal inhibitory concentration; IFN, interferon; ISRE, interferon-stimulated response element.