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Vitamin D3 metabolism in patients with rheumatic diseases: Low serum levels of 25-hydroxyvitamin D3 in patients with systemic lupus erythematosus

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Summary

1,25-dihydroxyvitamin D3 (1,25(OH)2 D3) has been shown to modulate lymphocyte activation in vitro. Through binding to specific receptors 1,25(OH)2 D3 inhibits proliferation, immunoglobulin production and the release of cytokines. Moreover, 1,25-(OH)2 D3 is efficiently produced by activated monocytes. These findings suggest that 1,25-(OH)2 D3 may play a role as a regulator of immunological activation. Consequently, we found it of interest to study the serum levels of the two major metabolites of vitamin D3 in patients with systemic lupus erythematosus (SLE) (n=21), rheumatoid arthritis (RA) (n=29) and osteoarthritis (n=12). In patients with SLE the levels of 25-OH D3 were below those of the healthy controls (p=0.0008) and OA (p=0.0168). The levels 1,25-(OH)2 D3 corresponded to normal levels. There were no significant correlations between 25-OH D3 levels and clinical or paraclinical disease manifestations. Further, the phenotypic distribution of Gc-globulin, which binds vitamin D3 metabolites in circulation, was normal. The serum concentrations of 1,25-(OH)2 D3 and 25-OH D3 in patients with RA and OA corresponded to those of the controls. Although the cause of the reduced 25-OH D3 levels in SLE patients is unclear, possible beneficial effects of administration of vitamin D to these patients should be considered.

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References

  1. Reichel, H., Koeffler, H.P., Norman, A.W. The role of the vitamin D endocrine system in health N Engl J Med 1989, 320, 980–991.

    PubMed  Google Scholar 

  2. Rigby, W.F.C. The immunobiology of vitamin D. Immunol Today 1988, 9, 54–58.

    PubMed  Google Scholar 

  3. Manolagas, S.C., Hustmyer, F.G., Yu, X.P. Immunomodulating properties of 1,25-dihydroxyvitamin D3. Kidney Int Suppl 1990, 29, S9–16.

    Google Scholar 

  4. Provvedini, D.M., Tsoukas, C.D., Deftos, L.J., Manolagas, S.C. 1,25-Dihydroxyvitamin D3 receptors in human leukocytes. Science 1983, 221, 1181–1182.

    PubMed  Google Scholar 

  5. Manolagas, S.C., Wernitz, D.A., Tsoukas, C.D., Provvedini, D.M., Vaughan, J.H. 1,25-Dihydroxyvitamin D3 receptors in lymphocytes from patients with rheumatoid arthritis. J Lab Clin Med 1986, 108, 596–600.

    PubMed  Google Scholar 

  6. Rigby, W.F., Stacy, T., Fanger, M.W. Inhibition of T lymphocyte mitogenesis by 1,25-dihydroxyvitamin D3 (calcitriol). J Clin Invest 1984, 74, 1451–1455.

    PubMed  Google Scholar 

  7. Müller, K., Svenson, M., Bendtzen, K. 1 alpha, 25-dihydroxyvitamin D3 and a novel vitamin D analogue. Immunol Lett 1988, 17, 361–365.

    PubMed  Google Scholar 

  8. Lemire, J.M., Adams, J.S., Sakai, R., Jordan, S.C. 1 alpha, 25-dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells. J Clin Invest 1984, 74, 657–661.

    PubMed  Google Scholar 

  9. Iho, S., Takahashi, T., Kura, F., Sugiyama, H., Hoshino, T. The effect of 1,25-dihydroxyvitamin D3 on in vitro immunoglobulin production by human B cells. J Immunol 1986, 136, 4427–4431.

    PubMed  Google Scholar 

  10. Müller, K., Heilmann, C., Poulsen, L.K., Barington, T., Bendtzen, K. The role of monocytes and T cells in 1,25 dihydroxyvitamin D3 mediated inhibition of B cell function in vitro. Immunopharmacology 1991, 21, 121–128.

    PubMed  Google Scholar 

  11. Tsoukas, C.D., Provvedini, D.M., Manolagas, S.C. 1,25 dihydroxyvitamin D3: a novel immunoregulatory hormone. Science 1984, 224, 1438–1440.

    PubMed  Google Scholar 

  12. Reichel, H., Koeffler, H.P., Tobler, A., Norman, A.W. 1,25-Dihydroxyvitamin D3 inhibits gamma-interferon synthesis by normal human peripheral blood lymphocytes. Proc Natl Acad Sci U S A 1987, 84, 3385–3389.

    PubMed  Google Scholar 

  13. Müller, K., Haahr, P.M., Diamant, M., Rieneck, K., Kharazmi, A., Bendtzen, K. 1,25-Dihydroxyvitamin D3 inhibits cytokine production by human blood monocytes at the posttranscriptional level. Cytokine 1992, 4, 506–512.

    PubMed  Google Scholar 

  14. Reichel, H., Koeffler, H.P., Bishop, J.E., Norman, A.W. 25-Hydroxylavitamin D3 metabolism by lipopolysaccharide-stimulated normal human marcophages. J Clin Endocrinol Metab 1987, 64, 1–9.

    PubMed  Google Scholar 

  15. Hayes, M.E., Denton, J., Freemont, A.J., Mawer, E.B. Synthesis of the active metabolite of vitamin D, 1,25 (OH) 2D3, by synovial fluid macrophages in arthritic diseases. Ann Rheum Dis 1989, 48, 723–729.

    PubMed  Google Scholar 

  16. Adams J.S., Sharma, O.P., Gacad, M.A., Singer, F.R. Metabolism of 25-hydroxyvitamin D3 by cultures pulmonary alveolar macrophages in sarcoidosis. J Clin Invest 1983, 72, 1856–1860.

    PubMed  Google Scholar 

  17. Mason, R.S., Frankel, T., Chan, Y., Lissner, D. Posen, S. Vitamin D conversion by sarcoid lymph node homogenate. Ann Intern Med 1984, 100, 59–61.

    PubMed  Google Scholar 

  18. Tan, E.M., Cohen, A.S., Fries, J.F. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982, 25, 1271–1277.

    PubMed  Google Scholar 

  19. Urowitz, M.B., Gladman, D.D., Tozman, E.C.S., Goldsmith, C.H. The lupus activity criteria count (LACC). J Rheumatol 1984, 11, 783–787.

    PubMed  Google Scholar 

  20. Pinals, R.S., Masi, A.T., Larsen, R.A. Preliminary criteria for clinical remission in rheumatoid arthritis. Arthritis Rheum 1981, 24, 1308.

    PubMed  Google Scholar 

  21. Arnett, F.C., Edworthy, S.M., Bloch, D.H., McShane, D.J., Fries, J.F., Cooper, N.S., Healey, L.A., Kaplan, S.R., Liang, M.H. The American Rheumatism Association 1987: revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988, 31, 315–324.

    PubMed  Google Scholar 

  22. Lund, B., Sørensen, O.H. Mearurement of 25-hydroxyvitamin D in serum and its relation to sunshine, age and vitamin D intake in the Danish population. Scand J Clin Lab Invest 1979, 39, 23–30.

    PubMed  Google Scholar 

  23. Lund, B., Sørensen, O.H. Measurement of circulating 1,25 dihydroxyvitamin in man. Changes in serum concentrations during treatment with 1 alfa hydroxycholecalciferol. Acta Endocr 1979, 91, 338–350.

    PubMed  Google Scholar 

  24. Thymann, M. Gc subtypes determined by agarose isoelectric focusing. Distribution in Denmark and application to paternity cases. Hum Hered 1981, 31, 214–221.

    PubMed  Google Scholar 

  25. Bird, H.A., Peacock, M., Storer, J.H., Wright, V. Comparison of serum 25-OH vitamin D concentration in rheumatoid arthritis and osteoarthrosis. Brit Med J 1980, 6229, 1416.

    Google Scholar 

  26. Mawer, E.B., Hayes, M.E., Still, P.E., Davies, M., Lumb, G.A.L., Palit, J., Holt, P.J.L. Evidence of nonrenal synthesis of 1,25-dihydroxyvitamin D in patients with inflammatory arthritis. J Bone Miner Res 1991, 6, 733–738.

    PubMed  Google Scholar 

  27. Als, O.S., Riis, B., Christiansen, C. Serum concentrations of vitamin D metabolites in rheumatoid arthritis. Clin Rheumatol 1987, 6, 238–243.

    PubMed  Google Scholar 

  28. Rico, H., Hernandez, E.R., Gomez-Castresana, F., Yagua, M., Cabranes, J.A., Valor, R. Osteopenia in rheumatoid arthritis: a biochemical, hormonal and histomorphometric study. Clin Rheumatol 1990, 9, 63–68.

    Google Scholar 

  29. Müller, K., Oxholm, P., Sørensen, O.H., Thymann, H., Høier-Madsen, M., Bendtzen, K. Abnormal vitamin D metabolism in patients with primary Sjögren's syndrome. Ann Rheum Dis 1989, 49, 682–684.

    Google Scholar 

  30. Prummel, M.F., Wiersinga, W.M., Lips, P., Sanders, G.T.B., Sauerwein, H.P. The course of biochemical parameters of bone turnover during treatment with glycocorticoids. J Clin Endocrinol Metab 1991, 72, 382–386.

    PubMed  Google Scholar 

  31. Gonates, N.K., Greene, M.I., Waksman, B.H. Genetic and molecular aspects of demyelination. Immunol Today 1986, 7, 121–126.

    Google Scholar 

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Authors and Affiliations

  1. Laboratory for Medical Immunology, Medical Department TTA, Rigshospitalet State University Hospital, Rigshospitalet, Tagensvej 20, DK-220, Copenhagen, Denmark

    K. Müller M.D., Ph. D., N. J. Kriegbaum & K. Bentzen

  2. Laboratory for Autoimmune Serology, State Serum Institute, Copenhagen, Denmark

    B. Baslund

  3. Osteoporosis Research Centre, Copenhagen Municipal Hospital, Copenhagen, Denmark

    O. H. Sørensen

  4. Institute of Forensic Genetics, University of Copenhagen, Copenhagen, Denmark

    M. Thymann

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  1. K. Müller M.D., Ph. D.
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  2. N. J. Kriegbaum
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  3. B. Baslund
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  4. O. H. Sørensen
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  5. M. Thymann
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  6. K. Bentzen
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Müller, K., Kriegbaum, N.J., Baslund, B. et al. Vitamin D3 metabolism in patients with rheumatic diseases: Low serum levels of 25-hydroxyvitamin D3 in patients with systemic lupus erythematosus. Clin Rheumatol 14, 397–400 (1995). https://doi.org/10.1007/BF02207671

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  • DOI: https://doi.org/10.1007/BF02207671

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