Splenectomy for cytopenias associated with systemic lupus erythematosus

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Summary

Splenectomy was performed in 20 patients withrefractory cytopenias associated with systemic lupus erythematosus. An immediate and sustained increase in platelet count (greater than 150,000 cells/mm3) was achieved in 12 of 18 patients whose principal indication for operation was thrombocytopenia. Of seven patients with hemolytic anemia, which was linked with thrombocytopenia in five, six had an increase in the hematocrit value of 20 percent or more after operation. The white blood count increased to normal values in three leukopenic patients. We believe that although removal of the spleen is not uniformly successful in correcting cytopenias in patients with systemic lupus erythematosus, splenectomy should be considered in patients refractory to other modalities of treatment.

References (7)

  • BreckenridgeRT et al.

    A study of thrombocytopenia: new histologic criteria for the differentiation of idiopathic thrombocytopenia and thrombocytopenia associated with disseminated lupus erythematosus

    Blood

    (1967)
  • HomanWP et al.

    The role of splenectomy in the treatment of thrombocytopenic purpura due to systemic lupus erythematosus

    Ann Surg

    (1978)
  • RiveroSJ et al.

    Splenectomy for hematocytopenia in systemic lupus erythematosus: a controlled appraisal

    Arch Intern Med

    (1979)
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1

From the Department of Surgery, The University of Michigan Medical Center, Ann Arbor, Michigan.

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