Original contributionThe natural interferon-α producing cells in systemic lupus erythematosus
Section snippets
Abbreviations
- ANA
antinuclear antibody
- BCR
B-cell receptor
- CFA
Freund’s complete adjuvant
- CpG
cytosine-guanine dinucleotide
- DC
dendritic cell
- dsDNA
double-stranded DNA
- FcγRII
Fcγ-receptor II
- HSV
herpes simplex virus
- IDDM
insulin dependent diabetes mellitus
- IFN
interferon
- IFNAR
interferon-α receptor
- IL
interleukin
- IRF
interferon regulatory factor
- mAb
monoclonal antibody
- NIPC
natural interferon-α producing cell
- ODN
oligodeoxyribonucleotide
- PBMC
peripheral blood mononuclear cells
- PDC
plasmacytoid DC
- RNP
ribonucleoprotein
- SLE
systemic lupus
Conclusion
The type I IFN system may play a pivotal role in the initiation and maintenance of the autoimmune process in SLE. Production of endogenous IFN-α inducers and continuous stimulation of NIPC to IFN-α secretion are key events in this process, leading to a vicious circle where autoimmune T and B cells are activated to sustained autoantibody production and generation of more IFN-α inducers. An important goal in search for better therapy of SLE patients is to learn how the production and action of
Acknowledgements
We thank all our colleagues who have greatly contributed to own data on which this review is based, especially Brita Cederblad, Maija-Leena Eloranta, Helena Vallin, Stina Blomberg, Ullvi Båve, Anders Bengtsson, Gunnar Sturfelt, Anders Perers, Anne Riesenfeld, Tanja Lovgren, Mattias Magnusson, and Lotta Sjöberg. Financial support was provided by the Swedish Medical Research Council, The Swedish Rheumatism Foundation, the 80-years foundation of King Gustaf V, Åke Wiberg foundation, Nanna Svartz
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