T-helper type 2–driven inflammation defines major subphenotypes of asthma

PG Woodruff, B Modrek, DF Choy, G Jia… - American journal of …, 2009 - atsjournals.org
Rationale: T-helper type 2 (Th2) inflammation, mediated by IL-4, IL-5, and IL-13, is
considered the central molecular mechanism underlying asthma, and Th2 cytokines are …

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

Y Zheng, PA Valdez, DM Danilenko, Y Hu, SM Sa… - Nature medicine, 2008 - nature.com
Infections by attaching and effacing (A/E) bacterial pathogens, such as Escherichia coli
O157: H7, pose a serious threat to public health. Using a mouse A/E pathogen, Citrobacter …

Molecular correlates of clinical response and resistance to atezolizumab in combination with bevacizumab in advanced hepatocellular carcinoma

AX Zhu, AR Abbas, MR de Galarreta, Y Guan, S Lu… - Nature medicine, 2022 - nature.com
Atezolizumab (anti-programmed death-ligand 1 (PD-L1)) and bevacizumab (anti-vascular
endothelial growth factor (VEGF)) combination therapy has become the new standard of …

TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma

DF Choy, KM Hart, LA Borthwick, A Shikotra… - Science translational …, 2015 - science.org
Increasing evidence suggests that asthma is a heterogeneous disorder regulated by distinct
molecular mechanisms. In a cross-sectional study of asthmatics of varying severity (n= 51) …

[HTML][HTML] Deconvolution of blood microarray data identifies cellular activation patterns in systemic lupus erythematosus

AR Abbas, K Wolslegel, D Seshasayee, Z Modrusan… - PloS one, 2009 - journals.plos.org
Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease with a complex
spectrum of cellular and molecular characteristics including several dramatic changes in the …

Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data

AR Abbas, D Baldwin, Y Ma, W Ouyang, A Gurney… - Genes & …, 2005 - nature.com
Immune cell-specific expression is one indication of the importance of a gene's role in the
immune response. We have compiled a compendium of microarray expression data for …

Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma

A Shikotra, DF Choy, CM Ohri, E Doran, C Butler… - Journal of allergy and …, 2012 - Elsevier
BACKGROUND: Thymic stromal lymphopoietin (TSLP) is a cytokine implicated in the
pathophysiology of asthma through 2 distinct pathways: a TSLP–OX40 ligand (OX40L)–T …

[PDF][PDF] Molecular subsets in renal cancer determine outcome to checkpoint and angiogenesis blockade

RJ Motzer, R Banchereau, H Hamidi, T Powles… - Cancer cell, 2020 - cell.com
Integrated multi-omics evaluation of 823 tumors from advanced renal cell carcinoma (RCC)
patients identifies molecular subsets associated with differential clinical outcomes to …

Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis

DJ DePianto, S Chandriani, AR Abbas, G Jia… - Thorax, 2015 - thorax.bmj.com
Background There is microscopic spatial and temporal heterogeneity of pathological
changes in idiopathic pulmonary fibrosis (IPF) lung tissue, which may relate to heterogeneity …

Safety and pharmacodynamics of rontalizumab in patients with systemic lupus erythematosus: results of a phase I, placebo‐controlled, double‐blind, dose‐escalation …

JM McBride, J Jiang, AR Abbas… - Arthritis & …, 2012 - Wiley Online Library
Objective Systemic lupus erythematosus (SLE) is a chronic autoimmune disease
characterized by the presence of autoantibodies and inflammation in multiple organ …