The authors' goal is to apply robotics and automation technology to assist, enhance,
quantify, and document neurorehabilitation. This paper reviews a clinical trial involving 20 …

In 1991, a novel robot, MIT-MANUS, was introduced to study the potential that robots might
assist in and quantify the neuro-rehabilitation of motor function. MIT-MANUS proved an …

Robotics and related technologies have begun to realize their promise to improve the
delivery of rehabilitation therapy. However, the mechanism by which they enhance recovery …

Background Effective rehabilitative therapies are needed for patients with long-term deficits
after stroke. Methods In this multicenter, randomized, controlled trial involving 127 patients …

Pivotal to brain development and function is an intact blood-brain barrier (BBB), which acts
as a gatekeeper to control the passage and exchange of molecules and nutrients between …

In systemic lupus erythematosus, antibodies against double-stranded DNA are a major
contributor to renal disease. We have previously demonstrated that the pentapeptide …

In this paper we describe the novel concept of performance-based progressive robot therapy
that uses speed, time, or EMG thresholds to initiate robot assistance. We pioneered the …

Background: We used MIT-Manus, a robot designed to provide interactive, goal-directed
motor activity for clinical neurologic applications. Objective: To test whether this robotic …

Patients with lupus (SLE) experience progressive cognitive loss without evidence of CNS
vascular disease or inflammation. SLE patients produce anti-DNA antibodies that crossreact …

Background Previous results with the planar robot MIT-MANUS demonstrated positive
benefits in trials with over 250 stroke patients. Consistent with motor learning, the positive …