Objective To develop new classification criteria for systemic lupus erythematosus (SLE)
jointly supported by the European League Against Rheumatism (EULAR) and the American …

Over the past 10 years, mitochondrial defects have been implicated in a wide variety of
degenerative diseases, aging, and cancer. Studies on patients with these diseases have …

Life is the interplay between structure and energy, yet the role of energy deficiency in human
disease has been poorly explored by modern medicine. Since the mitochondria use …

Abstract Objective The Systemic Lupus International Collaborating Clinics (SLICC) group
revised and validated the American College of Rheumatology (ACR) systemic lupus …

Leber's hereditary optic neuropathy is a maternally inherited disease resulting in optic nerve
degeneration and cardiac dysrhythmia. A mitochondrial DNA replacement mutation was …

In the US, approximately 35% of adults with systemic lupus erythematosus (SLE) have
clinical evidence of nephritis at the time of diagnosis, with an estimated total of 50–60 …

Background Allergic rhinitis (AR) affects 10% to 40% of the population. It reduces quality of
life and school and work performance and is a frequent reason for office visits in general …

The concentration of CO2 in the atmosphere has risen from close to 280 parts per million
(ppm) in 1800, at first slowly and then progressively faster to a value of 367 ppm in 1999 …

Using inorganic carbon measurements from an international survey effort in the 1990s and a
tracer-based separation technique, we estimate a global oceanic anthropogenic carbon …

This document builds on the previous Joint Task Force document ''Allergen immunotherapy:
a practice parameter second update''published in the Journal of Allergy and Clinical …