In the past decade, the emergence of machine learning (ML) applications has led to
significant advances towards implementation of personalised medicine approaches for …

Lipid rafts is a blanket term used to describe distinct areas in the plasma membrane rich in
certain lipids and proteins and which are thought to perform diverse functions. A large …

Suppressing inflammation has been the primary focus of therapies in autoimmune rheumatic
diseases (AIRDs), including rheumatoid arthritis and systemic lupus erythematosus …

Background A subset of patients with severe COVID-19 develop a hyperinflammatory
syndrome, which might contribute to morbidity and mortality. This study explores a specific …

The ultimate goal for the treatment of autoimmunity is to restore immunological tolerance.
Regulatory T cells (Treg) play a central role in immune tolerance, and Treg functional …

B cells perform many immunological functions, including presenting lipid antigen to CD1d-
restricted invariant natural killer T (iNKT) cells, known to contribute to maintaining tolerance …

Systemic lupus erythematosus (SLE) is characterized by abnormalities in T lymphocyte
receptor–mediated signal transduction pathways. Our previous studies have established …

Patients with the autoimmune rheumatic disease systemic lupus erythematosus (SLE) have
multiple defects in lymphocyte signaling and function that contribute to disease …

Determining divergent metabolic requirements of T cells, and the viruses and tumours they
fail to combat, could provide new therapeutic checkpoints. Inhibition of acyl-CoA: cholesterol …

Loss of tolerance to self-Ags in patients with systemic lupus erythematosus (SLE), a
prototypic autoimmune disease, is associated with dysregulation of T cell signaling …