C-reactive protein as a cardiovascular risk factor: more than an epiphenomenon?

WK Lagrand, CA Visser, WT Hermens, HWM Niessen… - Circulation, 1999 - Am Heart Assoc
Background—Circulating levels of C-reactive protein (CRP) may constitute an independent
risk factor for cardiovascular disease. How CRP as a risk factor is involved in cardiovascular …

Increased accumulation of the glycoxidation product Nε-(carboxymethyl) lysine in hearts of diabetic patients: generation and characterisation of a monoclonal anti …

CG Schalkwijk, A Baidoshvili, CDA Stehouwer… - … et Biophysica Acta (BBA …, 2004 - Elsevier
Heart failure is a condition closely linked to diabetes. Hyperglycaemia amplifies the
generation of a major advanced glycation end product Nε-(carboxymethyl) lysine (CML) …

Diagnosis of myocarditis: Current state and future perspectives

PS Biesbroek, AM Beek, T Germans… - International journal of …, 2015 - Elsevier
Myocarditis, ie inflammation of the myocardium, is one of the leading causes of sudden
cardiac death (SCD) and dilated cardiomyopathy (DCM) in young adults, and is an important …

Myocardial infarction accelerates atherosclerosis

P Dutta, G Courties, Y Wei, F Leuschner, R Gorbatov… - Nature, 2012 - nature.com
During progression of atherosclerosis, myeloid cells destabilize lipid-rich plaques in the
arterial wall and cause their rupture, thus triggering myocardial infarction and stroke …

[HTML][HTML] Viral presence and immunopathology in patients with lethal COVID-19: a prospective autopsy cohort study

B Schurink, E Roos, T Radonic, E Barbe… - The Lancet …, 2020 - thelancet.com
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) targets
multiple organs and causes severe coagulopathy. Histopathological organ changes might …

Diastolic stiffness of the failing diabetic heart: importance of fibrosis, advanced glycation end products, and myocyte resting tension

L Van Heerebeek, N Hamdani, ML Handoko… - Circulation, 2008 - Am Heart Assoc
Background—Excessive diastolic left ventricular stiffness is an important contributor to heart
failure in patients with diabetes mellitus. Diabetes is presumed to increase stiffness through …

Myocardial structure and function differ in systolic and diastolic heart failure

L van Heerebeek, A Borbély, HWM Niessen… - Circulation, 2006 - Am Heart Assoc
Background—To support the clinical distinction between systolic heart failure (SHF) and
diastolic heart failure (DHF), left ventricular (LV) myocardial structure and function were …

[HTML][HTML] Human bone marrow-and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species

SR Baglio, K Rooijers, D Koppers-Lalic… - Stem cell research & …, 2015 - Springer
Introduction Administration of mesenchymal stem cells (MSCs) represents a promising
treatment option for patients suffering from immunological and degenerative disorders …

C-reactive protein colocalizes with complement in human hearts during acute myocardial infarction

WK Lagrand, HWM Niessen, GJ Wolbink, LH Jaspars… - Circulation, 1997 - Am Heart Assoc
Background Rises in circulating C-reactive protein (CRP), the prototypical acute-phase
protein in humans, correlate with clinical outcome in patients with myocardial ischemia and …

Low myocardial protein kinase G activity in heart failure with preserved ejection fraction

L van Heerebeek, N Hamdani, I Falcão-Pires… - Circulation, 2012 - Am Heart Assoc
Background—Prominent features of myocardial remodeling in heart failure with preserved
ejection fraction (HFPEF) are high cardiomyocyte resting tension (Fpassive) and …