Background Neonatal-onset multisystem inflammatory disease is characterized by fever,
urticarial rash, aseptic meningitis, deforming arthropathy, hearing loss, and mental …

Background Antinuclear antibody (ANA) tests are frequently used to screen children for
chronic inflammatory diseases such as systemic lupus erythematosus (SLE). However, the …

Objective. To examine complaints for which children were referred to a pediatric
rheumatology service and to determine whether there are specific complaints that are more …

Objective To examine the role of children's illness-related cognitive appraisals in the parent-
child adjustment relationship in a sample of children and adolescents with juvenile …

The blood–brain barrier (BBB) plays a crucial role in brain homeostasis, thereby maintaining
the brain environment precise for optimal neuronal function. Its dysfunction is an intriguing …

Although strong epidemiologic evidence suggests an important role for adaptive immunity in
the pathogenesis of polyarticular juvenile rheumatoid arthritis (JRA), there remain many …

The social unrest of the past several months highlights the importance of ensuring that
science and fact-based objectivity align with the public discourse. A deepening body of …

Objective Examine caregiver demand and general parent distress as mediators in the parent
illness uncertainty—child depressive symptom association in youth with juvenile rheumatic …

Background The transcriptional complexity of mammalian cells suggests that they have
broad abilities to respond to specific environmental stimuli and physiologic contexts. These …

Juvenile idiopathic arthritis (JIA) has long been assumed to be an autoimmune disease,
triggered by aberrant recognition of" self" antigens by T-cells. However, systems biology …