The idiopathic hypereosinophilic syndrome: clinical, pathophysiologic, and therapeutic considerations
The idiopathic hypereosinophilic syndrome (HES) represents a heterogeneous group of
disorders with the common features of prolonged eosinophilia of an undetectable cause and …
disorders with the common features of prolonged eosinophilia of an undetectable cause and …
Recent insights into the genetic basis of systemic lupus erythematosus
KL Moser, JA Kelly, CJ Lessard, JB Harley - Genes & Immunity, 2009 - nature.com
Genetic variation was first shown to be important in systemic lupus erythematosus (SLE or
lupus) in the 1970s with associations in the human leukocyte antigen region. Almost four …
lupus) in the 1970s with associations in the human leukocyte antigen region. Almost four …
Epstein-Barr virus and molecular mimicry in systemic lupus erythematosus
Systemic lupus erythematosus (SLE or lupus) is a complex disease with a multifactoral
etiology, with genetic, hormonal, and environmental influences. Molecular mimicry as a …
etiology, with genetic, hormonal, and environmental influences. Molecular mimicry as a …
[HTML][HTML] Development of autoantibodies before the clinical onset of systemic lupus erythematosus
MR Arbuckle, MT McClain, MV Rubertone… - … England Journal of …, 2003 - Mass Medical Soc
Background Although much is known about the natural history of systemic lupus
erythematosus (SLE), the development of SLE autoantibodies before the diagnosis of the …
erythematosus (SLE), the development of SLE autoantibodies before the diagnosis of the …
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
… for Systemic Lupus Erythematosus Genetics (SLEGEN … - Nature …, 2008 - nature.com
Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with
complex etiology but strong clustering in families (λ S=∼ 30). We performed a genome-wide …
complex etiology but strong clustering in families (λ S=∼ 30). We performed a genome-wide …
A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans
L Prokunina, C Castillejo-López, F Öberg… - Nature …, 2002 - nature.com
Systemic lupus erythematosus (SLE, OMIM 152700) is a complex autoimmune disease that
affects 0.05% of the Western population, predominantly women 1, 2, 3, 4. A number of …
affects 0.05% of the Western population, predominantly women 1, 2, 3, 4. A number of …
Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus
Monozygotic (MZ) twins are partially concordant for most complex diseases, including
autoimmune disorders. Whereas phenotypic concordance can be used to study heritability …
autoimmune disorders. Whereas phenotypic concordance can be used to study heritability …
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome
Sjögren's syndrome is a common autoimmune disease (affecting∼ 0.7% of European
Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we …
Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we …
An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus.
JA James, KM Kaufman, AD Farris… - The Journal of …, 1997 - Am Soc Clin Investig
An unknown environmental agent has been suspected to induce systemic lupus
erythematosus (lupus) in man. Prompted by our recent immunochemical findings, we sought …
erythematosus (lupus) in man. Prompted by our recent immunochemical findings, we sought …
Systemic lupus erythematosus in adults is associated with previous Epstein‐Barr virus exposure
JA James, BR Neas, KL Moser, T Hall… - … : Official Journal of …, 2001 - Wiley Online Library
Objective The possible molecular mimicry of the Epstein‐Barr virus (EBV) peptide
PPPGRRP by the peptide PPPGMRPP from Sm B′/B of the human spliceosome is …
PPPGRRP by the peptide PPPGMRPP from Sm B′/B of the human spliceosome is …