User profiles for "author:John B Harley"

John B Harley

- Verified email at va.gov - Cited by 54649

John B Harley

- Verified email at cchmc.org - Cited by 3864

The idiopathic hypereosinophilic syndrome: clinical, pathophysiologic, and therapeutic considerations

AS Fauci, JB HARLEY, WC ROBERTS… - Annals of internal …, 1982 - acpjournals.org
The idiopathic hypereosinophilic syndrome (HES) represents a heterogeneous group of
disorders with the common features of prolonged eosinophilia of an undetectable cause and …

Recent insights into the genetic basis of systemic lupus erythematosus

KL Moser, JA Kelly, CJ Lessard, JB Harley - Genes & Immunity, 2009 - nature.com
Genetic variation was first shown to be important in systemic lupus erythematosus (SLE or
lupus) in the 1970s with associations in the human leukocyte antigen region. Almost four …

Epstein-Barr virus and molecular mimicry in systemic lupus erythematosus

BD Poole, RH Scofield, JB Harley, JA James - Autoimmunity, 2006 - Taylor & Francis
Systemic lupus erythematosus (SLE or lupus) is a complex disease with a multifactoral
etiology, with genetic, hormonal, and environmental influences. Molecular mimicry as a …

[HTML][HTML] Development of autoantibodies before the clinical onset of systemic lupus erythematosus

MR Arbuckle, MT McClain, MV Rubertone… - … England Journal of …, 2003 - Mass Medical Soc
Background Although much is known about the natural history of systemic lupus
erythematosus (SLE), the development of SLE autoantibodies before the diagnosis of the …

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

… for Systemic Lupus Erythematosus Genetics (SLEGEN … - Nature …, 2008 - nature.com
Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with
complex etiology but strong clustering in families (λ S=∼ 30). We performed a genome-wide …

A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans

L Prokunina, C Castillejo-López, F Öberg… - Nature …, 2002 - nature.com
Systemic lupus erythematosus (SLE, OMIM 152700) is a complex autoimmune disease that
affects 0.05% of the Western population, predominantly women 1, 2, 3, 4. A number of …

Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus

BM Javierre, AF Fernandez, J Richter… - Genome …, 2010 - genome.cshlp.org
Monozygotic (MZ) twins are partially concordant for most complex diseases, including
autoimmune disorders. Whereas phenotypic concordance can be used to study heritability …

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

CJ Lessard, H Li, I Adrianto, JA Ice, A Rasmussen… - Nature …, 2013 - nature.com
Sjögren's syndrome is a common autoimmune disease (affecting∼ 0.7% of European
Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we …

An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus.

JA James, KM Kaufman, AD Farris… - The Journal of …, 1997 - Am Soc Clin Investig
An unknown environmental agent has been suspected to induce systemic lupus
erythematosus (lupus) in man. Prompted by our recent immunochemical findings, we sought …

Systemic lupus erythematosus in adults is associated with previous Epstein‐Barr virus exposure

JA James, BR Neas, KL Moser, T Hall… - … : Official Journal of …, 2001 - Wiley Online Library
Objective The possible molecular mimicry of the Epstein‐Barr virus (EBV) peptide
PPPGRRP by the peptide PPPGMRPP from Sm B′/B of the human spliceosome is …