Cytosolic DNA-sensing pathways that signal via Stimulator of interferon genes (STING)
mediate immunity to pathogens and also promote autoimmune pathology in DNaseII-and …

Mature B cell pools retain a substantial proportion of polyreactive and self-reactive
clonotypes, suggesting that activation checkpoints exist to reduce the initiation of …

Systemic lupus erythematosus (SLE) is a chronic, life-threatening autoimmune disorder,
leading to multiple organ pathologies and kidney destruction. Analyses of numerous murine …

Central B cell tolerance is believed to be regulated by B cell receptor signaling induced by
the recognition of self-antigens in immature B cells. Using humanized mice with defective …

Endosomal TLRs play an important role in systemic autoimmune diseases, such as systemic
erythematosus lupus, in which DNA-and RNA-associated autoantigens activate autoreactive …

Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to systemic and
articular bone loss by activating bone resorption and suppressing bone formation. Despite …

BACKGROUND Influenza A virus (IAV) and SARS-CoV-2 are pandemic viruses causing
millions of deaths, yet their clinical manifestations are distinctly different. METHODS With the …

In mice that fail to express the phagolysosomal endonuclease DNase II and the type I IFN
receptor, excessive accrual of undegraded DNA results in a STING-dependent, TLR …

Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease affecting multiple
organs characterized by a complex interplay of immune cells, factors and pathways resulting …

Interferon regulatory factor 5-deficient (IRF5−/−) mice have been used for many studies of
IRF5 biology. A recent report identifies a mutation in dedicator of cytokinesis 2 (DOCK2) as …