User profiles for "author:Peter Kraft"

Peter Kraft

Harvard TH Chan School of Public Health
Verified email at hsph.harvard.edu
Cited by 113091

Improving reporting standards for polygenic scores in risk prediction studies

H Wand, SA Lambert, C Tamburro, MA Iacocca… - Nature, 2021 - nature.com
Polygenic risk scores (PRSs), which often aggregate results from genome-wide association
studies, can bridge the gap between initial discovery efforts and clinical applications for the …

Methodological challenges in mendelian randomization

TJ VanderWeele, EJT Tchetgen, M Cornelis… - Epidemiology, 2014 - journals.lww.com
We give critical attention to the assumptions underlying Mendelian randomization analysis
and their biological plausibility. Several scenarios violating the Mendelian randomization …

Exploiting gene-environment interaction to detect genetic associations

P Kraft, YC Yen, DO Stram, J Morrison… - Human heredity, 2007 - karger.com
Complex disease by definition results from the interplay of genetic and environmental
factors. However, it is currently unclear how gene-environment interaction can best be used …

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

BF Voight, LJ Scott, V Steinthorsdottir, AP Morris… - Nature …, 2010 - nature.com
By combining genome-wide association data from 8,130 individuals with type 2 diabetes
(T2D) and 38,987 controls of European descent and following up previously unidentified …

Hundreds of variants clustered in genomic loci and biological pathways affect human height

H Lango Allen, K Estrada, G Lettre, SI Berndt… - Nature, 2010 - nature.com
Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association …

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

IM Heid, AU Jackson, JC Randall, TW Winkler, L Qi… - Nature …, 2010 - nature.com
Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

A Okbay, BML Baselmans, JE De Neve, P Turley… - Nature …, 2016 - nature.com
Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a …

A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

DJ Hunter, P Kraft, KB Jacobs, DG Cox, M Yeager… - Nature …, 2007 - nature.com
We conducted a genome-wide association study (GWAS) of breast cancer by genotyping
528,173 SNPs in 1,145 postmenopausal women of European ancestry with invasive breast …

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

M Liu, Y Jiang, R Wedow, Y Li, DM Brazel, F Chen… - Nature …, 2019 - nature.com
Tobacco and alcohol use are leading causes of mortality that influence risk for many
complex diseases and disorders. They are heritable, and etiologically related, behaviors that …

An expanded genome-wide association study of type 2 diabetes in Europeans

RA Scott, LJ Scott, R Mägi, L Marullo, KJ Gaulton… - Diabetes, 2017 - Am Diabetes Assoc
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency
spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D …