X chromosome dose and sex bias in autoimmune diseases: increased prevalence of 47, XXX in systemic lupus erythematosus and Sjögren's syndrome
Objective More than 80% of autoimmune disease predominantly affects females, but the
mechanism for this female bias is poorly understood. We suspected that an X chromosome …
mechanism for this female bias is poorly understood. We suspected that an X chromosome …
Antiadrenergic autoimmunity in postural tachycardia syndrome
A Fedorowski, H Li, X Yu, KA Koelsch, VM Harris… - Ep …, 2017 - academic.oup.com
Aims Postural tachycardia syndrome (POTS), a common and debilitating cardiovascular
disorder, is characterized by an exaggerated heart rate increase during orthostasis and a …
disorder, is characterized by an exaggerated heart rate increase during orthostasis and a …
Protein detection by Simple Western™ analysis
VM Harris - Western Blotting: Methods and Protocols, 2015 - Springer
Protein Simple© has taken a well-known protein detection method, the western blot, and
revolutionized it. The Simple Western™ system uses capillary electrophoresis to identify and …
revolutionized it. The Simple Western™ system uses capillary electrophoresis to identify and …
Klinefelter's syndrome (47, XXY) is in excess among men with Sjögren's syndrome
Primary Sjögren's syndrome (pSS) has a strong female bias. We evaluated an X
chromosome dose effect by analyzing 47, XXY (Klinefelter's syndrome, 1 in 500 live male …
chromosome dose effect by analyzing 47, XXY (Klinefelter's syndrome, 1 in 500 live male …
[PDF][PDF] Genetics in Sjögren's syndrome: Where we are and where we go
VM Harris, RH Scofield, KL Sivils - Clin. Exp. Rheumatol, 2019 - clinexprheumatol.org
Sjögren's syndrome is a complex autoimmune disease that involves dysregulation of
immune responses that preferentially target exocrine glands. Systemic manifestations vary …
immune responses that preferentially target exocrine glands. Systemic manifestations vary …
[HTML][HTML] Lysosomal pH Is Regulated in a Sex Dependent Manner in Immune Cells Expressing CXorf21
VM Harris, ITW Harley, BT Kurien, KA Koelsch… - Frontiers in …, 2019 - frontiersin.org
Background: CXorf21 and SLC15a4 both contain risk alleles for systemic lupus
erythematosus (SLE) and Sjögren's syndrome (pSS). The former escapes X inactivation. Our …
erythematosus (SLE) and Sjögren's syndrome (pSS). The former escapes X inactivation. Our …
[HTML][HTML] Characterization of cxorf21 provides molecular insight into female-bias immune response in SLE pathogenesis
VM Harris, KA Koelsch, BT Kurien, ITW Harley… - Frontiers in …, 2019 - frontiersin.org
Background: Ninety percent of systemic lupus erythematosus (SLE) patients are women. X
chromosome-dosage increases susceptibility to SLE and primary Sjögren's syndrome (pSS) …
chromosome-dosage increases susceptibility to SLE and primary Sjögren's syndrome (pSS) …
Brief Report: Rare X Chromosome Abnormalities in Systemic Lupus Erythematosus and Sjögren's Syndrome
Objective Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE) are related by
clinical and serologic manifestations as well as genetic risks. Both diseases are more …
clinical and serologic manifestations as well as genetic risks. Both diseases are more …
[HTML][HTML] GnRH increases glucose transporter-1 expression and stimulates glucose uptake in the gonadotroph
VM Harris, SV Bendre… - Journal of …, 2012 - joe.bioscientifica.com
Synthesis of both mRNA and peptide for gastrin-releasing peptide (GRP) has been
demonstrated in the pregnant endometrium of sheep and women. However, it is not known …
demonstrated in the pregnant endometrium of sheep and women. However, it is not known …
Significantly reduced lymphadenopathy, salivary gland infiltrates and proteinuria in MRL-lpr/lpr mice treated with ultrasoluble curcumin/turmeric: increased survival …
BT Kurien, VM Harris, SMS Quadri… - Lupus science & …, 2015 - lupus.bmj.com
Objectives Commercial curcumin (CU), derived from food spice turmeric (TU), has been
widely studied as a potential therapeutic for a variety of oncological and inflammatory …
widely studied as a potential therapeutic for a variety of oncological and inflammatory …