Gastric parietal cells migrate from the luminal to the basal region of the gland, and they
gradually lose acid secretory activity. So far, distribution and function of K+-Cl-cotransporters …

Fibromyalgia is characterized by chronic widespread musculoskeletal pain. A hypofunction
in descending pain inhibitory systems is considered to be involved in the chronic pain of …

[(Dihydroindenyl) oxy] acetic acid (DIOA) has been used as a potent inhibitor of K+–Cl−
cotransporter (IC50= 10 μM). Here we found that DIOA inhibited activities of P-type ATPases …

It is known that specific alteration of rhythm in temperature (SART) stress produces somatic
pain. However, it remains to be investigated whether SART stress induces visceral pain. In …

Background Because M1 muscarinic receptors are expressed by enteric neurons, we
investigated whether positive allosteric modulators of these receptors (M1PAMs) would …

Background The major symptoms of irritable bowel syndrome (IBS) are changes in bowel
habits and abdominal pain. Psychological stress is the major pathophysiological …

Background and aims Auto-antibodies to nuclear constituents and type I Interferons (IFN)
such as IFN-a play key roles in pathogenesis of Systemic Lupus Erythematosus (SLE) …

Background and aims Pathogenic auto-antibodies produced by plasma cells are key drivers
of many auto-immune diseases such as Systemic Lupus Erythematosus (SLE), Rheumatoid …

抄録 K-Cl cotransporters (KCCs) play significant roles in epithelial transport and cell volume
regulation. Four KCC isoforms (KCC1-4) have been so far reported. We examined whether …

抄録 For gastric acid (HCl) secretion, protons are actively secreted by H+, K+-ATPase in the
apical membrane of gastric parietal cells, but it has not been established what molecule …