Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

CJ Lessard, H Li, I Adrianto, JA Ice, A Rasmussen… - Nature …, 2013 - nature.com
Sjögren's syndrome is a common autoimmune disease (affecting∼ 0.7% of European
Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we …

[HTML][HTML] Transancestral mapping and genetic load in systemic lupus erythematosus

CD Langefeld, HC Ainsworth, DSC Graham… - Nature …, 2017 - nature.com
Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and
ethnic disparities. We report a large transancestral association study of SLE using …

End‐Stage Renal Disease in African Americans With Lupus Nephritis Is Associated With APOL1

BI Freedman, CD Langefeld, KK Andringa… - Arthritis & …, 2014 - Wiley Online Library
Objective Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus
(SLE) that exhibits familial aggregation and may progress to end‐stage renal disease …

Defining disease activity states and clinically meaningful improvement in primary Sjögren's syndrome with EULAR primary Sjögren's syndrome disease activity …

R Seror, H Bootsma, A Saraux, SJ Bowman… - Annals of the …, 2016 - ard.bmj.com
Objectives To define disease activity levels, minimal clinically important improvement (MCII)
and patient-acceptable symptom state (PASS) with the primary Sjögren's syndrome (SS) …

Validation of EULAR primary Sjögren's syndrome disease activity (ESSDAI) and patient indexes (ESSPRI)

R Seror, E Theander, JG Brun… - Annals of the …, 2015 - ard.bmj.com
Objectives To validate the two recently developed disease activity indexes for assessment of
primary Sjögren's syndrome (SS): the European League Against Rheumatism (EULAR) SS …

[HTML][HTML] Interferons in Sjögren's syndrome: genes, mechanisms, and effects

H Li, JA Ice, CJ Lessard, KL Sivils - Frontiers in immunology, 2013 - frontiersin.org
Sjögren's syndrome (SS) is a common, progressive autoimmune exocrinopathy
distinguished by dry eyes and mouth and affects∼ 0.7% of the European population …

Genome‐wide DNA methylation patterns in naive CD4+ T cells from patients with primary Sjögren's syndrome

N Altorok, P Coit, T Hughes, KA Koelsch… - Arthritis & …, 2014 - Wiley Online Library
Objective Primary Sjögren's syndrome (SS) is a systemic autoimmune disease with
incompletely understood etiology. This study was undertaken to investigate the role of …

How immunological profile drives clinical phenotype of primary Sjogren's syndrome at diagnosis: analysis of 10,500 patients (Sjogren Big Data Project)

P Brito-Zerón, N Acar-Denizli, WF Ng… - Clinical and …, 2018 - research.rug.nl
Objective. To evaluate the influence of the main immunological markers on the disease
phenotype at diagnosis in a large international cohort of patients with primary Sjogren's …

[HTML][HTML] Genome-wide association study identifies Sjögren's risk loci with functional implications in immune and glandular cells

B Khatri, KL Tessneer, A Rasmussen… - Nature …, 2022 - nature.com
Sjögren's disease is a complex autoimmune disease with twelve established susceptibility
loci. This genome-wide association study (GWAS) identifies ten novel genome-wide …

X chromosome dose and sex bias in autoimmune diseases: increased prevalence of 47, XXX in systemic lupus erythematosus and Sjögren's syndrome

K Liu, BT Kurien, SL Zimmerman… - Arthritis & …, 2016 - Wiley Online Library
Objective More than 80% of autoimmune disease predominantly affects females, but the
mechanism for this female bias is poorly understood. We suspected that an X chromosome …